Abstract
In the last few decades, advances in the cancer chemotherapy have been a marked success. A large number of anticancer drugs currently in use include drugs based on platinum complexes such as cisplatin, base analogues such as 5-florouracil and some ruthenium drugs. This review provides a bird’s eye view of interaction of a number of clinically important drugs currently in use that show covalent or non-covalent interaction with serum proteins. Platinum drug-cisplatin interacts covalently and alters the function of the key plasma protease inhibitor molecule -alpha-2-macroglobulin and induces the conformational changes in the protein molecule and inactivates it. 5-fluorouracil (5-FU) is extensively metabolized and at physiological concentrations, is found to be associated with Human Serum Albumin (HSA). Similarly ruthenium compounds bind tightly to plasma proteins- serum albumin and serum transferrin, modifying their biological activity and increasing the toxicity of drug to cancer cells. Insight into varied anticancer drug- protein interaction will go a long way in understanding in totality of the mechanism of action of any anticancer drug and its possible effects/side effects.
Keywords: Alpha-2-macroglobulin, cisplatin, 5-FU, chemotherapeutic drugs, plasma proteins, new dimensions.
Graphical Abstract
Current Protein & Peptide Science
Title:Chemotherapeutic Drugs and Plasma Proteins: Exploring New Dimensions
Volume: 19 Issue: 10
Author(s): Mohammad Khalid Zia, Tooba Siddiqui, Syed Saqib Ali, Ahmed Abdur Rehman, Haseeb Ahsan and Fahim Halim Khan*
Affiliation:
- Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh,India
Keywords: Alpha-2-macroglobulin, cisplatin, 5-FU, chemotherapeutic drugs, plasma proteins, new dimensions.
Abstract: In the last few decades, advances in the cancer chemotherapy have been a marked success. A large number of anticancer drugs currently in use include drugs based on platinum complexes such as cisplatin, base analogues such as 5-florouracil and some ruthenium drugs. This review provides a bird’s eye view of interaction of a number of clinically important drugs currently in use that show covalent or non-covalent interaction with serum proteins. Platinum drug-cisplatin interacts covalently and alters the function of the key plasma protease inhibitor molecule -alpha-2-macroglobulin and induces the conformational changes in the protein molecule and inactivates it. 5-fluorouracil (5-FU) is extensively metabolized and at physiological concentrations, is found to be associated with Human Serum Albumin (HSA). Similarly ruthenium compounds bind tightly to plasma proteins- serum albumin and serum transferrin, modifying their biological activity and increasing the toxicity of drug to cancer cells. Insight into varied anticancer drug- protein interaction will go a long way in understanding in totality of the mechanism of action of any anticancer drug and its possible effects/side effects.
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Cite this article as:
Zia Khalid Mohammad , Siddiqui Tooba , Ali Saqib Syed, Rehman Abdur Ahmed , Ahsan Haseeb and Khan Halim Fahim*, Chemotherapeutic Drugs and Plasma Proteins: Exploring New Dimensions, Current Protein & Peptide Science 2018; 19 (10) . https://dx.doi.org/10.2174/1389203718666171002115547
DOI https://dx.doi.org/10.2174/1389203718666171002115547 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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