Abstract
Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved mechanisms of interacting pairs, functional domains and characterizing specific molecular interaction of host and pathogen is critical. In this era of advanced research in medical and pharmaceutical sciences, the treatment of severe diseases is being tackled at genetic and PPI level. In this review, a brief introduction and application of PPI is described. Moreover, the classifications of PPI and their application in diseases are highlighted. Furthermore, methods for prediction of PPI are also discussed including brief introduction and update on detection techniques. We hope this review will prove to be very helpful for researchers to get better understanding and update on PPI.
Keywords: Computation tools, disease, drug design, effector molecule, protein-protein interactions, structure.
Graphical Abstract
Current Protein & Peptide Science
Title:Protein-protein Interactions and their Role in Various Diseases and their Prediction Techniques
Volume: 19 Issue: 10
Author(s): Gulam Rabbani, Mohammad Hassan Baig, Khurshid Ahmad and Inho Choi*
Affiliation:
- Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541,Korea
Keywords: Computation tools, disease, drug design, effector molecule, protein-protein interactions, structure.
Abstract: Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved mechanisms of interacting pairs, functional domains and characterizing specific molecular interaction of host and pathogen is critical. In this era of advanced research in medical and pharmaceutical sciences, the treatment of severe diseases is being tackled at genetic and PPI level. In this review, a brief introduction and application of PPI is described. Moreover, the classifications of PPI and their application in diseases are highlighted. Furthermore, methods for prediction of PPI are also discussed including brief introduction and update on detection techniques. We hope this review will prove to be very helpful for researchers to get better understanding and update on PPI.
Export Options
About this article
Cite this article as:
Rabbani Gulam , Baig Hassan Mohammad , Ahmad Khurshid and Choi Inho *, Protein-protein Interactions and their Role in Various Diseases and their Prediction Techniques, Current Protein & Peptide Science 2018; 19 (10) . https://dx.doi.org/10.2174/1389203718666170828122927
DOI https://dx.doi.org/10.2174/1389203718666170828122927 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers