Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology

Author(s): Jignesh Lunagariya, Poonam Bhadja, Shenghui Zhong, Rohit Vekariya and Shihai Xu*

Volume 19, Issue 9, 2019

Page: [751 - 761] Pages: 11

DOI: 10.2174/1389557517666170927154231

Price: $65

Abstract

Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates for diverse biological targets. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin which has been isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, was tested for several therapeutic potentials such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti- larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activities as well as a means of other chemical agents. Herein, we summarized the discovery and isolation of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects. Additionally, synthesis of caulerpin and its functional analogues have also been reviewed.

Keywords: Bis-indole alkaloid, caulerpin, biological activity, marine natural product, total synthesis, secondary metabolites.

Graphical Abstract

[1]
Molinski, T.F.; Dalisay, D.S.; Lievens, S.L.; Saludes, J.P. Drug development from marine natural products. Nat. Rev. Drug Discov., 2009, 8, 69-85.
[2]
Haefner, B. Drugs from the deep: Marine natural products as drug candidates. Drug Discov. Today, 2003, 8(12), 536-544.
[3]
Simmons, T.L.; Andrianasolo, E.; McPhail, K.; Flatt, P.; Gerwick, W.H. Marine natural products as anticancer drugs. Mol. Cancer Ther., 2005, 4(2), 333-342.
[4]
Gao, J.; Hamann, M.T. Chemistry and biology of kahalalides. Chem. Rev., 2011, 111, 3208-3235.
[5]
Koehn, F.E.; Carter, G.T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov., 2004, 4, 206-220.
[6]
Mayer, A.M.; Glaser, K.B.; Cuevas, C.; Jacobs, R.S.; Kem, W.; Little, R.D.; McIntosh, J.M.; Newman, D.J.; Potts, B.C.; Shuster, D.E. The odyssey of marine pharmaceuticals: A current pipeline perspective. Trends Pharmacol. Sci., 2010, 31(6), 255-265.
[7]
Krause, J.; Tobin, G. Discovery; Development, and Regulation of Natural Products, InTech, 2013.
[http://dx.doi.org/10.5772/56424]
[8]
Williams, D.H.; Stone, M.J.; Hauck, P.R.; Rahman, S.K. Why are secondary metabolites (natural products) biosynthesized? J. Nat. Prod., 1989, 52, 1189-1208.
[9]
Firn, R.D.; Jones, C.G. Natural products: A simple model to explain chemical diversity. Nat. Prod. Rep., 2003, 20, 382-391.
[10]
Zähner, H. What are secondary metabolites? Folia Microbiol., 1979, 24(5), 435-443.
[11]
Hu, G.P.; Yuan, J.; Sun, L.; She, Z.G.; Wu, J.H.; Lan, X.J.; Zhu, X.; Lin, Y.C.; Chen, S.P. Statistical research on marine natural products based on data obtained between 1985 and 2008. Mar. Drugs, 2011, 9, 514-525.
[12]
Gul, W.; Hamann, M.T. Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases. Life Sci., 2005, 78, 442-453.
[13]
França, P.H.B.; Barbosa, D.P.; da Silva, D.L.; Ribeiro, Ê.A.N.; Santana, A.E.G.; Santos, B.V.O.; Barbosa-Filho, J.M.; Quintans, J.S.S.; Barreto, R.S.S.; Quintans-Júnior, L.J.; de Araújo-Júnior, J.X. Indole alkaloids from marine sources as potential leads against infectious diseases BioMed. Res. Int, 2014, 2014
[14]
Güven, K.C.; Percot, A.; Sezik, E. Alkaloids in marine algae. Mar. Drugs, 2010, 8, 269-284.
[15]
Kochanowska-Karamyan, A.J.; Hamann, M.T. Marine indole alkaloids: potential new drug leads for the control of depression and anxiety. Chem. Rev., 2010, 110, 4489-4497.
[16]
Williams, J.E. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on uña de gato and sangre de grado. Altern. Med. Rev., 2001, 6, 567-579.
[17]
Liu, D-Q.; Mao, S-C.; Zhang, H-Y.; Yu, X-Q.; Feng, M-T.; Wang, B.; Feng, L-H.; Guo, Y-W. Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa. Fitoterapia, 2013, 91, 15-20.
[18]
aKnolker, H-J.; Reddy, K.R. Isolation and synthesis of biologically active carbazole alkaloids. Chem. Rev., 2002, 102, 4303-4427.
bHibino, S.; Choshi, T. Simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Nat. Prod. Rep., 2001, 18, 66-87.
cNishizawa, Y. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, 1984, 308, 693-698.
dNishizawa, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature, 1988, 334, 661-665.
eNishizawa, Y. Studies and perspectives of protein kinase C. Science, 1986, 233, 305-312.
fStewart, A.F.; Schultz, G. Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene. Cell, 1987, 50, 1109-1117.
gMerino, A.; Madden, K.R.; Lane, W.S.; Champoux, D. DNA topoisomerase I is involved in both repression and activation of transcription. Nature, 1993, 365, 227-232.
[19]
Rubnov, S.; Chevallier, C.; Thoison, O.; Debitus, C.; Laprevote, O.; Guénard, D.; Sévenet, T. Echinosulfonic acid D: An ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp. Nat. Prod. Res., 2005, 19, 75-79.
[20]
Reyes, F.; Fernández, R.; Rodríguez, A.; Bueno, S.; de Eguilior, C.; Francesch, A.; Cuevas, C. Cytotoxic staurosporines from the marine ascidian Cystodytes solitus. J. Nat. Prod., 2008, 71, 1046-1048.
[21]
Jimenez, P.C.; Wilke, D.V.; Ferreira, E.G.; Takeara, R.; de Moraes, M.O.; Silveira, E.R.; da Cruz Lotufo, T.M.; Lopes, N.P.; Costa-Lotufo, L.V. Structure elucidation and anticancer activity of 7-oxostaurosporine derivatives from the Brazilian endemic tunicate Eudistoma vannamei. Mar. Drugs, 2012, 10, 1092-1102.
[22]
aKobayashi, J.; Murayama, T.; Ishibashi, M.; Kosuge, S.; Takamatsu, M.; Ohizumi, Y.; Kobayashi, H.; Ohta, T.; Nozoe, S.; Sasaki, T. Hyrtiosins A and B, new indole alkaloids from the Okinawan marine sponge Hyrtios erecta. Tetrahedron, 1990, 46, 7699-7702.
bBergman, J.; Venemalm, L. Synthesis of cyclopent[b]indolones. Tetrahedron, 1990, 46, 6061-6066.
[23]
aBartik, K.; Braekman, J-C.; Daloze, D.; Stoller, C.; Huysecom, J.; Vandevyer, G.; Ottinger, R. Topsentins, new toxic bis-indole alkaloids from the marine sponge Topsentiagenitrix. Can. J. Chem., 1987, 65, 2118-2121.
bTsuji, S.; Rinehart, K.L.; Gunasekera, S.P.; Kashman, Y.; Cross, S.S.; Lui, M.S.; Pomponi, S.A.; Diaz, M.C. Topsentin, Bromotopsentin, and Dihydrodeoxybromotopsentin: Antiviral and Antitumor bis (indolyl)imidazoles from Caribbean deep-sea sponge of the family Halichondriidae. Structural and synthetic studies. J. Org. Chem., 1988, 53, 5446-5453.
cMorris, S.A.; Andersen, R.J. Nitrogenous metabolites from the deep water sponge Hexadella sp. Can. J. Chem., 1989, 67, 677-681.
dMurray, L.M.; Lim, T.K.; Hooper, J.N.A.; Capon, R.J. Isobromotopsentin: a new bis(indo1e) alkaloid from a deep-water marine sponge Spongosorites sp. Aust. J. Chem., 1995, 48, 2053-2058.
eShin, J.; Seo, Y.; Cho, K.W.; Rho, J-R.; Sim, C.J. New bis(indole)alkaloids of the topsentin class from the sponge Spongosorites genitrix. J. Nat. Prod., 1999, 62, 647-649.
[24]
aBonjouklian, R.; Smitka, T.A.; Doolin, L.E.; Molloy, R.M.; Debono, M.; Shaffer, S.A.; Moore, R.E.; Stewart, J.B.; Patterson, G.M.L. Tjipanazoles, new antifungal agents from the blue-green alga Tolypothrix tjipanasensis. Tetrahedron, 1991, 47, 7739-7750.
bKuethe, J.T.; Wong, A.; Davies, I.W. Effective strategy for the preparation of indolocarbazole aglycons and glycosides: Total synthesis of tjipanazoles B, D, E, and I. Org. Lett., 2003, 5, 3721-3723.
cGilbert, E.J.; Ziller, J.W.; Van Vranken, D.L. Cyclizations of unsymmetrical bis-1,2-(3-indolyl)ethanes: Synthesis of (−)-tjipanazole F1. Tetrahedron, 1997, 53, 16553-16564.
[25]
aSu, J-Y.; Zhu, Y.; Zeng, L-M.; Xu, X-H. A new bisindole from alga Caulerpa serrulata. J. Nat. Prod., 1997, 60, 1043-1044.
bWahlstrom, N.; Stensland, B.; Bergman, J. Synthesis of the marine alkaloid caulersin. Tetrahedron, 2004, 60, 2147-2153.
cBourderioux, A.; Routier, S.; Beneteau, V.; Merour, J-Y. Synthesis of benzo analogues of oxoarcyriaflavins and caulersine. Tetrahedron, 2007, 63, 9465-9475.
dMiki, Y.; Aoki, Y.; Miyatake, H.; Minematsu, T.; Hibino, H. Synthesis of caulersin and its isomers by reaction of indole-2,3-dicarboxylic anhydrides with methyl indoleacetates. Tetrahedron Lett., 2006, 47, 5215-5218.
[26]
Aguilar-Santos, G. Caulerpin, a new red pigment from green algae of the genus Caulerpa. J. Chem. Soc., 1970, 6, 842-843. [C].
[27]
Aguilar-Santos, G. Doty. M.S. in Drugs from the sea (1968) (Freudenthal, H.D., ed.) p. 173 Marin Technology Society, Washington, DC
[28]
Dumay, O.; Fernandez, C.; Pergent, G. Primary production and vegetative cycle in Posidonia oceanica when in competition with the green algae Caulerpa taxifolia and Caulerpa racemosa. J. Mar. Biol. Assoc. U. K., 2002, 82, 379-387.
[29]
Capon, R.J.; Ghisalberti, E.L.; Jefferies, P.R. Metabolites of the green algae, Caulerpa Species. Phytochemistry, 1983, 22(6), 1465-1467.
[30]
Vest, S.E.; Dawes, C.J.; Romeo, J.T. Distribution of caulerpin and caulerpicin in eight species of the green alga Caulerpa (Caulerpales). Bot. Mar., 1983, XXVI, 313-316.
[31]
Schwede, J.G.; Cardellina, J.H.; Grode, S.H.; James, Jr, T.R.; Blackman, A.J. Distribution of the pigment caulerpin in species of the green alga Caulerpa. Phytochemistry, 1987, 26(1), 155-158.
[32]
Raub, M.F.; Cardellina, J.H.; Schwede, J.G. The green algal pigment caulerpin as a plant growth regulator. Phytochemistry, 1987, 26, 619-620.
[33]
Anjaneyulu, A.S.R.; Prakash, C.V.S.; Mallavadhani, U.V. Two caulerpin analogues and a sesquiterpene from Caulerpa racemosa. Phytochemistry, 1991, 30(9), 3041-3042.
[34]
Govenkar, M.B.; Wahidulla, S. Constituents of Chondria armata. Phytochemistry, 2000, 54, 979-981.
[35]
Vottero, E.; Balgi, A.; Woods, K.; Tugendreich, S.; Melese, T.; Andersen, R.J.; Grant Mauk, A.; Roberge, M. Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast. Biotechnol. J., 2006, 1, 282-288.
[36]
Mao, S-C.; Guo, Y-W.; Shen, X. Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorg. Med. Chem. Lett., 2006, 16, 2947-2950.
[37]
Rocha, F.D.; Soares, A.R.; Houghton, P.J.; Pereira, R.C.; Kaplan, M.A.C.; Teixeira, V.L. Potential cytotoxic activity of some Brazilian seaweeds on human melanoma cells. Phytother. Res., 2007, 21, 170-175.
[38]
de Souza, É.T.; de Lira, D.P.; de Queiroz, A.C.; da Silva, D.J.C.; de Aquino, A.B.; Campessato Mella, E.A.; Lorenzo, V.P.; de Miranda, G.E.C.; de Araújo-Júnior, J.X.; de Oliveira Chaves, M.C.; Barbosa-Filho, J.M.; de Athayde-Filho, P.F.; de Oliveira Santos, B.V.; Alexandre-Moreira, M.S. The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa. Mar. Drugs, 2009, 7, 689-704.
[39]
Alarif, W.M.; Abou-Elnaga, Z.S.; Ayyad, S-E.N.; Al-lihaibi, S.S. Insecticidal metabolites from the green alga Caulerpa racemosa. Clean Soil, Air. Water, 2010, 38(5-6), 548-557.
[40]
Kamal, C.; Sethuraman, M.G. Caulerpin-a bis-indole alkaloid as a green inhibitor for the corrosion of mild steel in 1 M HCl solution from the marine alga Caulerpa racemosa. Ind. Eng. Chem. Res., 2012, 51, 10399-10407.
[41]
Macedo, N.R.P.V.; Ribeiro, M.S.; Villaça, R.C.; Ferreira, W.; Pinto, A.M.; Teixeira, V.L.; Cirne-Santos, C.; Paixão, I.C.N.P.; Giongo, V. Caulerpin as a potential antiviral drug against herpes simplex virus type 1. Rev. Bras. Farmacogn., 2012, 22(4)
[42]
Pinto, A.M.V.; Leite, J.P.G.; Ferreira, W.J.; Cavalcanti, D.N.; Villaça, R.C.; Giongo, V.; Teixeira, V.L.; de Palmer Paixão, I.C.N. Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus. Rev. Bras. Farmacogn., 2012, 22(4)
[43]
Cavalcante-Silva, L.H.A.; de Carvalho Correia, A.C.; Barbosa-Filho, J.M.; da Silva, B.A.; de Oliveira Santos, B.V.; de Lira, D.P.; Sousa, J.C.F.; de Miranda, G.E.C.; de Andrade Cavalcante, F.; Alexandre-Moreira, M.S. Spasmolytic effect of caulerpine involves blockade of Ca2+ influx on guinea pig ileum. Mar. Drugs, 2013, 11, 1553-1564.
[44]
Nagappan, T.; Vairappan, C.S. Nutritional and bioactive properties of three edible species of green algae, genus Caulerpa (Caulerpaceae). J. Appl. Phycol., 2014, 26, 1019-1027.
[45]
Maiti, B.C.; Thomson, R.H.; Mahendran, M.J. The structure of caulerpin, a pigment from Caulerpa algae. Chem. Res. Synop, 1978, 4, 126-127.
[46]
Canché Chay, C.I.; Cansino, R.G.; Espitia Pinzón, C.I.; Torres-Ochoa, R.O.; Martínez, R. Synthesis and anti-tuberculosis activity of the marine natural product caulerpin and its analogues. Mar. Drugs, 2014, 12, 1757-1772.
[47]
Talaz, O.; Saracoglu, N. A study on the synthesis of structural analogues of bis-indole alkaloid caulerpin: A step-by-step synthesis of a cyclic indole-tetramer. Tetrahedron, 2010, 66, 1902-1910.
[48]
Vidal, J.P.; Laurent, D.; Kabore, S.A.; Rechencq, E.; Boucard, M.; Girard, J.P.; Escale, R.; Rossi, J.C. Caulerpin, caulerpicin, Caulerpa scalpelliformis: comparative acute toxicity study. Bot. Mar., 1984, XXVII, 533-537.
[49]
Schwede, J.G. Process for promoting and regulating plant growth with caulerpin. U.S. Patent 4,608,077, August 26. 1986.
[50]
Liu, L.; Pohnert, G.; Wei, D. Extracellular metabolites from industrial microalgae and their biotechnological potential. Mar. Drugs, 2016, 14, 191.
[51]
Saltiel, A.R.; Kahn, C.R. Insulin signaling and the regulation of glucose and lipid metabolism. Nature, 2001, 414, 799-806.
[52]
Obici, S.; Feng, Z.; Karkanias, G.; Baskin, D.G.; Rossetti, L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci., 2002, 5, 566-572.
[53]
Saltiel, A.R.; Pessin, J.E. Insulin signaling pathways in time and space. Trends Cell Biol., 2002, 12, 65-71.
[54]
Bryant, N.J.; Govers, R.; James, D.E. Regulated transport of the glucose transporter GLUT4. Nat. Rev. Mol. Cell Biol., 2002, 3, 267-277.
[55]
Smith, U. Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance — is insulin resistance initiated in the adipose tissue? Int. J. Obes. Relat. Metab. Disord., 2002, 26, 897-904.
[56]
Ostman, A.; Bohmer, F.D. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases. Trends Cell Biol., 2001, 11, 258-266.
[57]
Cheng, A.; Dube, N.; Gu, F.; Tremblay, M.L. Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur. J. Biochem., 2002, 269, 1050-1059.
[58]
Goldstein, B.J.; Bittner-Kowalczyk, A.; White, M.F.; Harbeck, M. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the GRB2 adaptor protein. J. Biol. Chem., 2000, 275, 4283-4289.
[59]
Johnson, T.O.; Ermolieff, J.; Jirousek, M.R. Protein tyrosine phosphatase 1b inhibitors for diabetes. Nat. Rev. Drug Discov., 2002, 1, 696-709.
[60]
Cavalcante-Silva, L.H.A.; Falcão, M.A.P.; Vieira, A.C.S.; Viana, M.D.M.; de Araújo-Júnior, J.X.; Sousa, J.C.F.; da Silva, T.M.S.; Barbosa-Filho, J.M.; Noël, F.; de Miranda, G.E.C.; de Oliveira Santos, B.V.; Alexandre-Moreira, M.S. Assessment of mechanisms involved in antinociception produced by the alkaloid caulerpine. Molecules, 2014, 19, 14699-14709.
[61]
Liu, Y.; Morgan, J.B.; Coothankandaswamy, V.; Liu, R.; Jekabsons, M.B.; Mahdi, F.; Nagle, D.G.; Zhou, Y-D. The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration. J. Nat. Prod., 2009, 72, 2104-2109.
[62]
Yu, H.; Zhang, H. Dong. M.; Wu. Z.; Shen. Z.; Xie, Y.; Kong, Z.; Dai, X.; Xu, B. Metabolic reprogramming and AMPKα1 pathway activation by caulerpin in colorectal cancer cells. Int. J. Oncol., 2017, 50, 161-172.
[63]
El-Bahnasawy, M.M.; Fadil, E.E.; Morsy, T.A. Mosquito vectors of infectious diseases: are they neglected health disaster in Egypt? J. Egypt. Soc. Parasitol., 2013, 43(2), 373-386.
[64]
Arduino, P.G.; Porter, S.R. Oral and perioral herpes simplex virus type 1 (HSV-1) infection: Review of its management. Oral Dis., 2006, 12, 254-270.
[65]
World Health Organization. Global Tuberculosis report 2016. WHO Press, World Health Organization, Geneva. 2016, ISBN: 978-92-4-156539-4.
[66]
Kumar, V.; Abbas, A.K.; Fausto, N.; Mitchell, R.N. Robbins Basic Pathology, 8th ed.; Saunders Elsevier: 2007, 516-522. ISBN 978-1- 4160-2973-1.
[67]
World Health Organization. "The sixteenth global report on tuberculosis. 2011.
[68]
Zumla, A.; Raviglione, M.; Hafner, R.; von Reyn, C.F. Tuberculosis. N. Engl. J. Med., 2013, 368(8), 745-755.
[69]
Moloney, M.G. Natural products as a source for novel antibiotics. Trends Pharmacol. Sci., 2016, 37(8), 689-701.
[70]
Chan, G.J.; Lee, A.C.; Baqui, A.H.; Tan, J.; Black, R.E. Risk of early-onset neonatal infection with maternal infection or colonization: A global systematic review and meta-analysis. PLoS Med., 2013, 10(8), e1001502.
[71]
Kumar, M.; Kumari, P.; Trivedi, N.; Shukla, M.K.; Gupta, V.; Reddy, C.R.K.; Jha, B. Minerals, PUFAs and antioxidant properties of some tropical seaweeds from Saurashtra coast of India. J. Appl. Phycol., 2011, 23, 797-810.
[72]
Wijesekara, I.; Pangestuti, R.; Kim, S-K. Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr. Polym., 2011, 84, 14-21.
[73]
Lorenzo, V.P.; Filho, J.M.B.; Scotti, L.; Scotti, M.T. Combined structure- and ligand-based virtual screening to evaluate caulerpin analogs with potential inhibitory activity against monoamine oxidase B. Rev. Bras. Farmacogn., 2015, 25, 690-697.

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version435msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[18:00:34] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[18:00:35] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[18:00:35] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (148ms)time
  • Application (287ms)time
  • 1 x Application (66.03%)
    287ms
    1 x Booting (33.97%)
    148ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    37 statements were executed, 4 of which were duplicates, 33 unique. Show only duplicated191ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59699349','',1,1739988034,1739988034) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739988034
      1.36msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59699349','/article/86031',1,1739988034,1739988034)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59699349 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59699349) limit 1
      20.91msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59699349
      • 1: 59699349
      • 2: 59699349
      • 3: 59699349
      • 4: 59699349
      • 5: 59699349
      • 6: 59699349
      • 7: 59699349
      • 8: 59699349
      • 9: 59699349
      • 10: 59699349
      • 11: 59699349
      • 12: 59699349
      • 13: 59699349
      • 14: 59699349
      • 15: 59699349
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=86031
      1.23msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 56 limit 1
      1.09msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 56
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and sj.journal_id!=56 group by `j`.`nid`) as `aggregate_table`
      1.25msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and sj.journal_id!=56 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      980μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.44msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.28msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '86031'
      290μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 86031
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '86031'
      3.29msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 86031
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '86031' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.57msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 86031
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      340μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      720μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 56 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      52.28msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 56 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      22.03msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 56 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      18.93msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 86031 limit 1
      300μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 86031
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 86031 and content_type = 'article' order by status desc limit 1
      1.55msalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 16 and cd.sub_disease_id = 443 and content_id!=86031 and cd.content_type = 'article' order by rand() limit 20
      46.01msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 155927 limit 1
      270μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 155927
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'MRMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      280μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: MRMC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '86031' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '9033' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      290μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2608' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      240μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2608) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2608) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2608)
      4.57msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 9033) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 9033) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 9033)
      660μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 86031) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 86031) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988035 and j.to_date >= 1739988035 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 86031)
      670μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '751' and is_uploaded = 1 and issue_id = 9033 order by cast(first_page as SIGNED) desc limit 1
      520μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 751
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '761' and is_uploaded = 1 and issue_id = 9033 order by cast(first_page as SIGNED) asc limit 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 761
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      220μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      240μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 86031 limit 1
      2.52msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 86031
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 56 and `b`.`banner_from_date` <= 1739988035 and `b`.`banner_to_date` >= 1739988035 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.21msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 56
      • 3: 1739988035
      • 4: 1739988035
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 56 and `b`.`banner_from_date` <= 1739988035 and `b`.`banner_to_date` >= 1739988035 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.2msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 56
      • 3: 1739988035
      • 4: 1739988035
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='065fcb02797e1de93aafb6a017d6c531'
      260μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        GhxoTPaEo0PPifUDdvUjNoDOeGBKD4pud5K890ux
        uc_cart_id
        065fcb02797e1de93aafb6a017d6c531
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/86031" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/86031
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Im41alR5VXFiN1JFVU5KdzFqWmVMMFE9PSIsInZhbHVlIjoicVA5NFlqWUxWMVJBQVFDRi8wUmVMeStPb0VpalhDZ2p4SU9ZZUdZOHJwWT0iLCJtYWMiOiJjNWNjYjFlNWYwMWUyNTM2NWI0YTNkN2FkNjg3NTRkMmQ1OTZjNjAxMGZkN2I4Y2Y0NTZjN2JhNGNhOTc3NzQyIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Im41alR5VXFiN1JFVU5KdzFqWmVMMFE9PSIsInZhbHVlIjoicVA5NFlqWUxWMVJBQVFDRi8wUmVMeStPb0VpalhDZ2p4SU9ZZUdZOHJwWT0iLCJtYWMiOiJjNWNjYjFlNWYwMWUy" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:00:35 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjRFbWxKWFFnQVJSaE0rRDBvOTlmTkE9PSIsInZhbHVlIjoiZm13Q2lmSG9ncGRBdFFJdHhEZm1EVDZlMHIzQ3Nkd1pyU25TSFNWV0ZHTWptMGZKK1owMG0vTWVVYmFOMVVxR3IzTWR4RlNnV3lBKzhXSWl1OUdDZkVxUDR4c01ZSU9tUEZzbFVhZ08yZVVYWm9LYTVuZ29veEt4clpEeVVwQ0wiLCJtYWMiOiJkODBjZmU5YTlkMTA1Njg3YzU2YzBhZmY4NzZkYjJkNTczOGIyNDMxYWYwYzJiZDk4YTNkYTdkOTcyZjgyOTg2IiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:00:35 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjRFbWxKWFFnQVJSaE0rRDBvOTlmTkE9PSIsInZhbHVlIjoiZm13Q2lmSG9ncGRBdFFJdHhEZm1EVDZlMHIzQ3Nkd1pyU25TSFNWV0ZHTWptMGZKK1owMG0vTWVVYmFOMVVxR3IzTWR4R" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjlSY0NJRWNsSThQL3VZbkhWcHU3elE9PSIsInZhbHVlIjoiVkNzK0RwQXY2Y2tnbE11SGwrTU9iZDYvTXRyMW05Rzh5L3JPQ3NtdFJjZGtsNDVCVDZ6KzMxM3d3YU9oTEVCUWRHWFVzRXV2ZXNjUk1uYm9yYnhKeGN5dkMyaWhsNVg3bldENWF2dXE5NzBYTTN5U1FhMC9oWVVBWmF5SGxZUU4iLCJtYWMiOiI2NmY3YjBhYmUyZTI2ZmM3NmFjZGJmYmM5MDc5MjBlZTJmMjI4YjZlN2Y3Y2ZlOTUxMTI3NmYzZDBmYTJkNDVhIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjlSY0NJRWNsSThQL3VZbkhWcHU3elE9PSIsInZhbHVlIjoiVkNzK0RwQXY2Y2tnbE11SGwrTU9iZDYvTXRyMW05Rzh5L3JPQ3NtdFJjZGtsNDVCVDZ6KzMxM3d" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjRFbWxKWFFnQVJSaE0rRDBvOTlmTkE9PSIsInZhbHVlIjoiZm13Q2lmSG9ncGRBdFFJdHhEZm1EVDZlMHIzQ3Nkd1pyU25TSFNWV0ZHTWptMGZKK1owMG0vTWVVYmFOMVVxR3IzTWR4RlNnV3lBKzhXSWl1OUdDZkVxUDR4c01ZSU9tUEZzbFVhZ08yZVVYWm9LYTVuZ29veEt4clpEeVVwQ0wiLCJtYWMiOiJkODBjZmU5YTlkMTA1Njg3YzU2YzBhZmY4NzZkYjJkNTczOGIyNDMxYWYwYzJiZDk4YTNkYTdkOTcyZjgyOTg2IiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:00:35 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjRFbWxKWFFnQVJSaE0rRDBvOTlmTkE9PSIsInZhbHVlIjoiZm13Q2lmSG9ncGRBdFFJdHhEZm1EVDZlMHIzQ3Nkd1pyU25TSFNWV0ZHTWptMGZKK1owMG0vTWVVYmFOMVVxR3IzTWR4R" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjlSY0NJRWNsSThQL3VZbkhWcHU3elE9PSIsInZhbHVlIjoiVkNzK0RwQXY2Y2tnbE11SGwrTU9iZDYvTXRyMW05Rzh5L3JPQ3NtdFJjZGtsNDVCVDZ6KzMxM3d3YU9oTEVCUWRHWFVzRXV2ZXNjUk1uYm9yYnhKeGN5dkMyaWhsNVg3bldENWF2dXE5NzBYTTN5U1FhMC9oWVVBWmF5SGxZUU4iLCJtYWMiOiI2NmY3YjBhYmUyZTI2ZmM3NmFjZGJmYmM5MDc5MjBlZTJmMjI4YjZlN2Y3Y2ZlOTUxMTI3NmYzZDBmYTJkNDVhIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjlSY0NJRWNsSThQL3VZbkhWcHU3elE9PSIsInZhbHVlIjoiVkNzK0RwQXY2Y2tnbE11SGwrTU9iZDYvTXRyMW05Rzh5L3JPQ3NtdFJjZGtsNDVCVDZ6KzMxM3d" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "GhxoTPaEo0PPifUDdvUjNoDOeGBKD4pud5K890ux" "uc_cart_id" => "065fcb02797e1de93aafb6a017d6c531" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/86031" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:00:35GET/article/86031314371