摘要
背景：刺激响应性载体是一类药物递送系统，其可响应特定刺激而改变其物理化学性质和/或结构构象。尽管被动和主动药物靶向已被证明可减少对正常细胞的副作用，但受控的细胞内药物释放应包括在药物载体中以增强药物在疾病部位的生物利用度。方法：本综述重点介绍了刺激响应性载体的最新进展，这些载体用于响应细胞内刺激（例如pH，氧化还原电位，活性氧，酶和温度）的治疗剂的空间和时间控制释放。 结果：在不同类型的刺激中，pH响应载体主要用于设计细胞内控释系统。内部和外部细胞之间的氧化还原电位的急剧差异归因于谷胱甘肽浓度的高度变化。通过感知不同水平的氧化条件，ROS响应性载体因选择性释放治疗剂而备受关注。利用酶作为刺激响应性载体的触发物的优点包括各种类型的酶，酶催化反应的高选择性和所涉及的温和反应条件。异常温度是另一种独特的刺激因素，已广泛用于触发肿瘤细胞中药物的控制释放。 结论：本文强调的最新发展表明，刺激响应载体作为控制细胞内药物释放的新平台具有巨大潜力。
关键词: 刺激反应性载体，细胞内药物释放，pH氧化还原电位，活性氧，酶，温度。
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