摘要
背景:分枝杆菌细胞壁的复杂结构负责这些病原体的许多生理和感染相关的特性。具有手性官能团的长链分枝菌酸构成主要的脂质包膜组分,因此在确定细胞壁的渗透性和流动性方面起关键作用。各种分枝杆菌中存在不同比例的不同分枝杆菌类型。这用来指定特定的霉菌酸谱,允许物种和亚种的分化。 目的:探讨霉菌酸化学结构的多样性,对细胞壁通透性的影响及毒力的后果,以及如何将其作为诊断和化疗的研究对象。 方法:搜索书目数据库以获得充分,翔实和有价值的同行评议文献。通过与专题领先的期刊,关键词,命名作者,参考扫描等相关的手工和电子检索,确定合适的论文。 结果:审查是基于92个精心挑选的文章,使这次审查提供最新的信息。过去五年内发表了二十九篇论文,其中十个在2016 - 2017年出版。 结论:相关文献的修订表明,分枝菌酸在寄主 - 病原菌相互作用中发挥着至关重要的作用,因此可能成为分枝杆菌菌种分化的有前途的工具,并发现新的杀结核菌治疗策略。
关键词: 霉菌酸,分枝杆菌,细胞壁渗透性,细胞壁流动性,毒力,诊断
Erratum In:
Diversity and Functionality of Mycobacterial Mycolic Acids in Relation to Host-pathogen Interactions
Current Medicinal Chemistry
Title:Diversity and Functionality of Mycobacterial Mycolic Acids in Relation to Host-pathogen Interactions
Volume: 24 Issue: 38
关键词: 霉菌酸,分枝杆菌,细胞壁渗透性,细胞壁流动性,毒力,诊断
摘要: Background: The complex architecture of the mycobacterial cell wall is responsible for many physiological and infection-associated properties of these pathogens. Long chain mycolic acids with chiral functional groups constitute a major lipid envelope component, and therefore play a crucial role in determining the permeability and fluidity of the cell wall. Varying proportions of the different mycolate types are present in various mycobacteria. This serves to designate a specific mycolic acid profile, allowing the differentiation of species and subspecies.
Objective: In this review, we explore the diversity in mycolic acid chemical structure, its influence on cell wall permeability and consequences for virulence, and present how they might be exploited as research targets in diagnosis and chemotherapy.
Methods: The search of bibliographic databases for adequate, informative and valuable peerreviewed literature was undertaken. The proper papers were identified by the hand and electronic searching through the relevant to the topic-leading journals, key words, named authors, reference scanning, etc.
Results: The review is based on the ninety two carefully selected articles that allow this review to provide up-to-date information. Twenty nine papers were published within last 5 years, including 10 showed up in 2016-2017.
Conclusion: The revision of the relevant literature showed that mycolic acids played a crucial role in host-pathogen interactions and thus might serve as a promising tool for differentiation of mycobacterial species and discovering novel tuberculocidal therapeutic strategies.
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Cite this article as:
Diversity and Functionality of Mycobacterial Mycolic Acids in Relation to Host-pathogen Interactions, Current Medicinal Chemistry 2017; 24 (38) . https://dx.doi.org/10.2174/0929867324666170823130445
DOI https://dx.doi.org/10.2174/0929867324666170823130445 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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