Abstract
Allergic diseases have substantially increased in all western countries and the cause of this increase would appear to be related to both environmental changes and the western lifestyle. There is a complex interaction between genetic and environmental factors that can influence the onset of allergic diseases. The activation of the innate immune system, caused by microbial stimulation, seems to have a key role in normal immune maturation. Several studies showed that the activities of intestinal microflora have a metabolic, trophic, and protective function also affecting immune tolerance. Particularly, the probiotics, live microbial food ingredients, are able to confer health benefits on the consumers. The aim of this review is summarized what is known in regard to the critical role of the probiotic on onset of allergic diseases.
Keywords: Allergic disease, allergy, children, immune tolerance, microflora, probiotics.
Graphical Abstract