摘要
背景:本研究旨在确定认知健康个体(CHI),轻度认知功能障碍(MCI)患者和轻度和中度痴呆患者的时空步态参数和/或其组合(S),无论病因如何的认知障碍。 方法:从洲际“步态,科学和衰退”(GOOD)计划中选择2099名参与者(1015名CHI,478名MCI患者,331名轻度痴呆患者和275名中度痴呆患者),合并不同的数据库横断面研究。平均值和变异系数(CoV)的时空步态参数记录在通常的步行与GAITRiteR系统。 结果:认知障碍的严重程度与所有步态参数的恶化有关。无论认知状态如何,步速都与认知功能障碍关系最为密切。步幅长度的高平均值和CoV表征中度痴呆,而步幅时间的CoV增加是MCI状态所特有的。 结论:本研究结果支持特定的认知障碍相关步态障碍的存在,认知功能障碍的不同阶段存在差异,可用于筛选认知障碍患者。
关键词: 流行病学,步态障碍,运动控制,认知障碍,步态评估,阿尔茨海默病。
Current Alzheimer Research
Title:Spatiotemporal Gait Characteristics Associated with Cognitive Impairment: A Multicenter Cross-Sectional Study, the Intercontinental “Gait, cOgnitiOn & Decline” Initiative
Volume: 15 Issue: 3
关键词: 流行病学,步态障碍,运动控制,认知障碍,步态评估,阿尔茨海默病。
摘要: Background: The study aims to determine the spatiotemporal gait parameters and/or their combination(s) that best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia, regardless of the etiology of cognitive impairment.
Methods: A total of 2099 participants (1015 CHI, 478 patients with MCI, 331 patients with mild dementia and 275 with moderate dementia) were selected from the intercontinental “Gait, cOgnitiOn & Decline” (GOOD) initiative, which merged different databases from seven cross-sectional studies. Mean values and coefficients of variation (CoV) of spatiotemporal gait parameters were recorded during usual walking with the GAITRite® system.
Results: The severity of cognitive impairment was associated with worse performance on all gait parameters. Stride velocity had the strongest association with cognitive impairment, regardless of cognitive status. High mean value and CoV of stride length characterized moderate dementia, whereas increased CoV of stride time was specific to MCI status.
Conclusion: The findings support the existence of specific cognitive impairment-related gait disturbances with differences related to stages of cognitive impairment, which may be used to screen individuals with cognitive impairment.
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Spatiotemporal Gait Characteristics Associated with Cognitive Impairment: A Multicenter Cross-Sectional Study, the Intercontinental “Gait, cOgnitiOn & Decline” Initiative, Current Alzheimer Research 2018; 15 (3) . https://dx.doi.org/10.2174/1567205014666170725125621
DOI https://dx.doi.org/10.2174/1567205014666170725125621 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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