Pro-angiogenic Molecules for Therapeutic Angiogenesis

Title:Pro-angiogenic Molecules for Therapeutic Angiogenesis

Volume: 24 Issue: 31

Author(s): Vignesh Selvaprithviraj, Deepthi Sankar, Amirthalingam Sivashanmugam, Sowmya Srinivasan and Rangasamy Jayakumar*

Affiliation:

• Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Amrita University, Kochi-682041,India

Keywords: Angiogenesis, pro-angiogenic molecules, growth factors, peptides, small molecules, inorganic nanoparticles, polysaccharides.

Abstract: Background: Therapeutic angiogenesis is a clinical intervention for controlled stimulation and augmentation of neovascularisation in ischemic tissues. Conventional therapeutic techniques involve proangiogenic factor based induction of host tissue angiogenesis. In this review, we provide a holistic idea about therapeutic angiogenesis while specifically highlighting the role of proangiogenic factors as growth factors, peptides, small molecules and polysaccharides in tissue neovascularisation.

Methods: A detailed search of peer-reviewed literature was carried out with prime focus on therapeutic angiogenesis and proangiogenic factors. The content of each literature reviewed in this paper was qualitatively analysed for particulars and relevance to the subject of study. This work has been distributed under four broad titles, namely, proangiogenic growth factors, peptides, small molecules and polysaccharides. Also, recent developments pertaining to proangiogenic factors for therapeutic angiogenesis have been detailed.

Results: A total of 244 literatures have been reviewed from the bibliographic database to present a conceptual understanding about the importance of proangiogenic factors in revascularisation of ischemic tissues.

Conclusion: This review focuses on importance of various proangiogenic factors, with reference to therapeutic angiogenesis. Thorough analysis of clinical data reveals the dearth of a defined system for proangiogenic growth factor delivery. Designing of a biomaterial based paradigm for growth factor therapy, might help in enhancing clinical translation of therapeutic angiogenesis.

Cite this article as:

Selvaprithviraj Vignesh, Sankar Deepthi, Sivashanmugam Amirthalingam, Srinivasan Sowmya and Jayakumar Rangasamy*, Pro-angiogenic Molecules for Therapeutic Angiogenesis, Current Medicinal Chemistry 2017; 24 (31) . https://dx.doi.org/10.2174/0929867324666170724142641