摘要
睾酮是人体内主要内源性雄激素合成类固醇。人体内睾酮水平与许多激素紊乱(性功能低下、阳痿等)主要与男性有关,并与前列腺癌、代谢综合征、肥胖、心血管疾病等多种疾病有关。睾酮在运动员中被广泛使用,他们愿意增加体力、侵略性和恢复能力,使之成为类固醇滥用中最常见的药物。在诊所和医院中,非常需要快速、简便和廉价的方法来评估睾酮。本文对不同生物样品,如血清、唾液、血浆、尿液或指甲样品中睾酮的测定方法进行了综述。在简要描述了这种类固醇激素在生物医学领域中的作用之后,描述了各种类型的测定方法。最重要的方法有免疫测定法、液相色谱串联质谱法和电化学法。为快速评估睾酮,设计了不同类型的传感器:免疫传感器、生物传感器、随机或多模传感器。我们可以得出结论,到目前为止,现有的分析方法可以涵盖广泛的浓度范围,能够检测儿童唾液中的睾酮水平(使用随机传感器),到全血,可以使用电化学、免疫学和色谱方法
关键词: 睾酮,传感器,免疫,随机,光谱,色谱。
Current Medicinal Chemistry
Title:Advanced Methods for the Analysis of Testosterone
Volume: 25 Issue: 33
关键词: 睾酮,传感器,免疫,随机,光谱,色谱。
摘要: Testosterone is the principal endogenous androgenic–anabolic steroid in humans. The levels of testosterone in the human body are correlated with many hormonal disorders (hypogonadism, impotence, etc) mostly in men, and with many types of diseases such as: prostate cancer, metabolic syndrome, obesity, cardiovascular diseases and so on. Testosterone is extensively used among sportsmen willing to increase strength, aggressiveness, and recovery; making it the most commonly reported substance in steroid abuse. Fast, easy and cheap methods for the evaluation of testosterone are extremely needed in clinics and hospitals. This review is dedicated to surveying recent determination methods of testosterone from different biological samples such as: serum, saliva, plasma, urine or fingernail samples. After a brief description of the role of this steroid hormone in the biomedical field, various types of determination methods are described. The most important methods are immunoassays, liquid chromatography tandem massspectrometry and electrochemical methods. Different types of sensors were designed for the rapid assessment of testosterone: immunosensors, biosensors, stochastic or multimode sensors. One can conclude that to date, the available methods of analysis can cover a wide concentration range, able to detect testosterone from children`s saliva, where the levels are the lowest (using stochastic sensors), to whole blood, where electrochemical, immunological and chromatographic methods can be used.
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Cite this article as:
Advanced Methods for the Analysis of Testosterone, Current Medicinal Chemistry 2018; 25 (33) . https://dx.doi.org/10.2174/0929867324666170724102602
DOI https://dx.doi.org/10.2174/0929867324666170724102602 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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