摘要
背景:铁是细菌,真菌和人类必需的微量营养素,因此,每个人都进化出专门的铁摄取系统以从细胞外环境获取铁。 目的:描述在这一重要营养素的争夺战中人类宿主与病原微生物之间进化出来的铁的复杂“拔河”。 方法:回顾当前的文献进行评估目前的方法和铁在人类中的治疗和螯合的争议。 结果:在人体中,从入侵病原体中螯合(隐藏)铁通常是成功的;然而,许多病原体已经发展出机制来绕过这种方法。 结论:在临床上,铁超负荷或铁给药是否会导致感染风险增加,争议仍在继续。将铁螯合剂和铁载体缀合物药物给予感染的宿主似乎是一种生物合理的方法,作为辅助治疗由依赖于宿主铁供应的病原体(例如结核,疟疾和许多细菌和真菌病原体)引起的感染的辅助治疗;然而,迄今为止,在人类的研究证明是不成功的。
关键词: 感染,铁,营养免疫,铁载体,铁超载,铁螯合。
Current Medicinal Chemistry
Title:The Battle for Iron between Humans and Microbes
Volume: 25 Issue: 1
关键词: 感染,铁,营养免疫,铁载体,铁超载,铁螯合。
摘要: Background: Iron is an essential micronutrient for bacteria, fungi, and humans; as such, each has evolved specialized iron uptake systems to acquire iron from the extracellular environment.
Objective: To describe complex ‘tug of war’ for iron that has evolved between human hosts and pathogenic microorganisms in the battle for this vital nutrient.
Methods: A review of current literature was performed, to assess current approaches and controversies in iron therapy and chelation in humans.
Results: In humans, sequestration (hiding) of iron from invading pathogens is often successful; however, many pathogens have evolved mechanisms to circumvent this approach.
Conclusion: Clinically, controversy continues whether iron overload or administration of iron results in an increased risk of infection. The administration of iron chelating agents and siderophore- conjugate drugs to infected hosts seems a biologically plausible approach as adjunctive therapy in the treatment of infections caused by pathogens dependent on host iron supply (e.g. tuberculosis, malaria, and many bacterial and fungal pathogens); however, thus far, studies in humans have proved unsuccessful.
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Cite this article as:
The Battle for Iron between Humans and Microbes, Current Medicinal Chemistry 2018; 25 (1) . https://dx.doi.org/10.2174/0929867324666170720110049
DOI https://dx.doi.org/10.2174/0929867324666170720110049 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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