摘要
背景：心房颤动（AF）与心源性卒中风险增加有关。口服抗凝药的使用并未充分降低心源性栓塞的风险，因为尽管接受了治疗，仍有许多患者继续出现血栓栓塞事件。因此，鉴定用于鉴定这些高风险患者的循环生物标志物将是临床有益的。 目的：在本文中，我们的目的是回顾有关使用生物标志物预测房颤患者心源性卒中的现有数据。 方法：我们对文献进行了全面的搜索，以分析迄今为止发现的生物标志物并批判性地评估其临床意义。 结果：已经提出许多生物标志物来预测AF患者的心源性卒中。其中一些已经用于临床实践，例如d-二聚体，肌钙蛋白和脑利钠肽。新的生物标志物，例如炎症生长分化因子-15，似乎是有希望的，而微RNA和遗传学的作用似乎也是有用的。尽管这些生物标志物与血栓栓塞风险增加有关，但它们无法准确预测未来事件。鉴于此，使用包含循环生物标志物和临床因素的评分系统可能更有用。 结论：最近的研究已经公开了几种生物标志物作为AF患者心源性卒中的潜在预测因子。然而，需要进一步研究建立一个多因素评分系统，以识别高血栓栓塞风险的患者，谁将受益于更强化的治疗和监测。
关键词: 心房颤动，心律失常，心源性卒中，生物标志物，血栓栓塞，中风预测。
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