纳米给药熊果酸抗癌价值研究进展

Title:Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery

Volume: 25 Issue: 37

关键词: 生物利用度，癌症，纳米医学，天然化合物，熊果酸，综述。

摘要: Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound. Nano-drug delivery systems may improve the pharmacokinetic, bioavailability, and therapeutic activity of some medicines. The present review has focused on recent developments regarding nano-drug delivery systems of ursolic acid in cancer therapy.

Cite this article as:

Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery, Current Medicinal Chemistry 2018; 25 (37) . https://dx.doi.org/10.2174/0929867324666170713102918