Immune Response to Native Lipoproteins Induces Visceral Obesity and Aortic Wall Injury in Rats: The Role of Testosterone

Title:Immune Response to Native Lipoproteins Induces Visceral Obesity and Aortic Wall Injury in Rats: The Role of Testosterone

Volume: 17 Issue: 2

Author(s): Kseniya Fomina, Liubov Beduleva*, Igor Menshikov, Marina Anikaeva, Daria Suntsova, Alexandr Sidorov and Elena Stolyarova

Affiliation:

• Department of Immunology and Cell Biology, Udmurt State University, 1, Universitetskaya St., Izhevsk,Russian Federation

Keywords: Atherosclerosis, visceral fat, native lipoproteins, antibodies, rat model, testosterone.

Abstract: Objectives: The underlying mechanism of atherosclerosis and visceral obesity remains unknown.The purpose of this study was to test the hypothesis that atherosclerosis and visceral obesity are caused by an immune response to native plasma lipoproteins, and the atherogenic and adipogenic effects of the antibodies to native lipoproteins stem from the androgen deficiency that is created.

Methods: Wistar rats were immunized with native human (nh) low-density (LDL) or high-density lipoproteins (HDL). Visceral fat, aortic wall structure, and testosterone levels were studied.

Results: Immunization with nhLDL or nhHDL induced in rats increased visceral abdominal fat and perivascular adipose tissue volume, the appearance of epicardial fat, and atherosclerosis-like changes in the aortic wall: accumulation of leucocytes, destruction of the intima, and disruption of the media structure. Immunized rats produced antibodies to native plasma lipoproteins, while there was no difference between immunized and adjuvant-injected rats with regard to the level of antibodies to oxidized LDL. The immune response to nhHDL caused testosterone disturbances, but it is not associated with visceral obesity and atherosclerosis.

Conclusion: The immune response to native lipoproteins is atherogenic and adipogenic and testosterone is not involved in the atherogenic and adipogenic effects of antibodies to lipoproteins.

Cite this article as:

Fomina Kseniya , Beduleva Liubov*, Menshikov Igor , Anikaeva Marina , Suntsova Daria , Sidorov Alexandr and Stolyarova Elena, Immune Response to Native Lipoproteins Induces Visceral Obesity and Aortic Wall Injury in Rats: The Role of Testosterone, Endocrine, Metabolic & Immune Disorders - Drug Targets 2017; 17 (2) . https://dx.doi.org/10.2174/1871530317666170711154825

DOI https://dx.doi.org/10.2174/1871530317666170711154825	Print ISSN 1871-5303
Publisher Name Bentham Science Publisher	Online ISSN 2212-3873