Abstract
Background: Nicotinamide phosphoribosyltransferase(Nampt) has a variety of biological effects, which can participate in the development of inflammatory diseases, metabolism diseases and chronic kidney disease, et al. However, the role of Nampt in T2DM and DN is still controversial. Objective: The study aimed to investigate changes in serum Nampt levels and its significance in diabetic nephropathy (DN).
Method: A total of 321 type 2 diabetes (T2DM) were divided into normal albuminuria group (NA, n=110), microalbuminuria group (MA, n=106) and large amount of albuminuria group (LA, n=105). 105 healthy persons were selected forming the control group (NC, n=105).; 118 T2DM without insulin therapy were screened out as the non–insulin therapy group (NIT.; n=116). Serum Nampt and interleukin (IL)-1β were measured by enzyme-linked immunosorbent assay. The relationships among the variables were analyzed by Pearson correlation analysis and Stepwise multiple regression analysis. Results: Serum Nampt and IL-1β in the LA group were significantly higher than other groups, and they were higher in MA than in the NA group (P<0.05). Serum Nampt was positively correlated with IL-1β and urinary albumin-to-creatinine ratio (UACR) (P <0.01), and IL-1β and UACR were independent relevant factors affecting Nampt. Serum Nampt was positively correlated with insulin resistance (HOMA-IR) but negatively correlated with the quantitative insulin sensitivity check index (QUICKI) (P <0.01) in the NIT group. Conclusion: We indicated that serum Nampt and IL-1β were increased accompanied by the increased UACR and the association between Nampt and insulin resistance and β-cell function in T2DM with different UACRs.Keywords: Type 2 diabetes, diabetic nephropathy, insulin resistance, inflammation, nampt, interleukin-1β.
Graphical Abstract
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Changes in Serum Nampt Levels and Its Significances in Diabetic Nephropathy Patients-The Potential Role of Nampt in T2DM with Diabetic Nephropathy
Volume: 17 Issue: 2
Author(s): Xiaoyu Ma, Li An and Qiuyue Wang*
Affiliation:
- Department of Endocrinology, First Hospital of China Medical University, Shenyang, Liaoning Province,China
Keywords: Type 2 diabetes, diabetic nephropathy, insulin resistance, inflammation, nampt, interleukin-1β.
Abstract: Background: Nicotinamide phosphoribosyltransferase(Nampt) has a variety of biological effects, which can participate in the development of inflammatory diseases, metabolism diseases and chronic kidney disease, et al. However, the role of Nampt in T2DM and DN is still controversial. Objective: The study aimed to investigate changes in serum Nampt levels and its significance in diabetic nephropathy (DN).
Method: A total of 321 type 2 diabetes (T2DM) were divided into normal albuminuria group (NA, n=110), microalbuminuria group (MA, n=106) and large amount of albuminuria group (LA, n=105). 105 healthy persons were selected forming the control group (NC, n=105).; 118 T2DM without insulin therapy were screened out as the non–insulin therapy group (NIT.; n=116). Serum Nampt and interleukin (IL)-1β were measured by enzyme-linked immunosorbent assay. The relationships among the variables were analyzed by Pearson correlation analysis and Stepwise multiple regression analysis. Results: Serum Nampt and IL-1β in the LA group were significantly higher than other groups, and they were higher in MA than in the NA group (P<0.05). Serum Nampt was positively correlated with IL-1β and urinary albumin-to-creatinine ratio (UACR) (P <0.01), and IL-1β and UACR were independent relevant factors affecting Nampt. Serum Nampt was positively correlated with insulin resistance (HOMA-IR) but negatively correlated with the quantitative insulin sensitivity check index (QUICKI) (P <0.01) in the NIT group. Conclusion: We indicated that serum Nampt and IL-1β were increased accompanied by the increased UACR and the association between Nampt and insulin resistance and β-cell function in T2DM with different UACRs.Export Options
About this article
Cite this article as:
Ma Xiaoyu, An Li and Wang Qiuyue *, Changes in Serum Nampt Levels and Its Significances in Diabetic Nephropathy Patients-The Potential Role of Nampt in T2DM with Diabetic Nephropathy, Endocrine, Metabolic & Immune Disorders - Drug Targets 2017; 17 (2) . https://dx.doi.org/10.2174/1871530317666170711164347
DOI https://dx.doi.org/10.2174/1871530317666170711164347 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Flow Cytometry Study of Leukocyte Function: Analytical Comparison of Methods and their Applicability to Clinical Research
Current Medicinal Chemistry Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation
Current Drug Targets The Place of Somatostatin Analogs in the Diagnosis and Treatment of the Neuoroendocrine Glands Tumors
Recent Patents on Anti-Cancer Drug Discovery Effects of Highly Active Antiretroviral Therapy on Albuminuria in HIV-infected Persons
Infectious Disorders - Drug Targets Sex Hormones, Metabolic Syndrome and Kidney
Current Topics in Medicinal Chemistry Influence of Diabetes on the Pharmacokinetic Behavior of Natural Polyphenols
Current Drug Metabolism Therapeutic Potential of Natural Products in Parkinson’s Disease
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) The Effect of Dual-Task Testing on Balance and Gait Performance in Adults with Type 1 or Type 2 Diabetes Mellitus: A Systematic Review
Current Diabetes Reviews Lipid-lowering Therapy in the Diabetic Foot: Seeing the Whole Iceberg and not Just the Tip
Current Vascular Pharmacology In-Silico Algorithms for the Screening of Possible microRNA Binding Sites and Their Interactions
Current Genomics Drug-Induced Anemia and Other Red Cell Disorders: A Guide in the Age of Polypharmacy
Current Clinical Pharmacology Gymnema sylvestre R. Br., an Indian Medicinal Herb: Traditional Uses, Chemical Composition, and Biological Activity
Current Pharmaceutical Biotechnology Pre-CKD- Do we Need Another Hero?
Current Vascular Pharmacology Walking the Oxidative Stress Tightrope: A Perspective from the Naked Mole-Rat, the Longest-Living Rodent
Current Pharmaceutical Design Novel Therapeutic Strategies for Cardiorenal Protection in Patients with Type 2 Diabetes and Chronic Kidney Disease
Current Vascular Pharmacology Selective Chemokine Receptor-Targeted Depletion of Pathological Cells as A Therapeutic Strategy for Inflammatory, Allergic and Autoimmune Diseases
Recent Patents on Inflammation & Allergy Drug Discovery Point-of-Care Testing in Diabetes Care
Mini-Reviews in Medicinal Chemistry Biochemical, Enzymatic and Molecular Properties of Renin/Prorenin Mediated by (Pro)Renin Receptor
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) From a Dull Enzyme to Something Else: Facts and Perspectives Regarding Aldose Reductase
Current Medicinal Chemistry Animal Models of Obesity and Metabolic Syndrome: Potential Tools for Alzheimers Disease Research
Current Alzheimer Research