摘要
哺乳动物的免疫系统是一个完美的防御系统,抛光了数亿年的演变。独特的灵活性和适应性已经为许多外来病原体创造了几乎难以逾越的障碍,这些病原体每一刻都在殴打我们。遗憾的是,仍然主要是神秘的触发器有时会说服免疫系统重新针对自身抗原。这场内战仍在进行之中,没有任何怜悯,也没有掳掠俘虏,最终导致人体不可逆转的病态变化。在过去二十年中出现的研究使我们有希望通过各种技术来“重置”免疫系统来克服自身免疫性疾病。在本报告中,我们总结了利用短多肽(主要是自身抗原的片段)治疗自身免疫性神经变性的最新进展。
关键词: 多发性硬化症,特异性变应原免疫治疗,耐受性,交叉反应性,自身反应性B细胞消除,自身抗体,免疫毒素,脂质体。
Current Medicinal Chemistry
Title:Peptides Against Autoimmune Neurodegeneration
Volume: 24 Issue: 17
关键词: 多发性硬化症,特异性变应原免疫治疗,耐受性,交叉反应性,自身反应性B细胞消除,自身抗体,免疫毒素,脂质体。
摘要: The mammalian immune system is a nearly perfect defensive system polished by a hundred million years of evolution. Unique flexibility and adaptivity have created a virtually impenetrable barrier to numerous exogenous pathogens that are assaulting us every moment. Unfortunately, triggers that remain mostly enigmatic will sometimes persuade the immune system to retarget against self-antigens. This civil war remains underway, showing no mercy and taking no captives, eventually leading to irreversible pathological changes in the human body. Research that has emerged during the last two decades has given us hope that we may have a chance to overcome autoimmune diseases using a variety of techniques to “reset” the immune system. In this report, we summarize recent advances in utilizing short polypeptides - mostly fragments of autoantigens - in the treatment of autoimmune neurodegeneration.
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Peptides Against Autoimmune Neurodegeneration, Current Medicinal Chemistry 2017; 24 (17) . https://dx.doi.org/10.2174/0929867324666170605092221
DOI https://dx.doi.org/10.2174/0929867324666170605092221 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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