Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents

Title:Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents

Volume: 15 Issue: 2

Author(s): Chekuri Sharmila Rani, Meda Haritha, Mandava V. Basaveswara Rao*Manojit Pal*

Affiliation:

• Department of Chemistry, Krishna University, Machilipatnam-521001, Andhra Pradesh,India

• Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046,India

Keywords: 2-amino benzo[h]chromene, MCR, Pd/C, cytotoxicity, cytotoxic agents, potential treatment.

Abstract: Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents.

Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step.

Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.

Cite this article as:

Rani Sharmila Chekuri , Haritha Meda, Basaveswara Rao V. Mandava *, Pal Manojit*, Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents, Letters in Drug Design & Discovery 2018; 15 (2) . https://dx.doi.org/10.2174/1570180814666170530094023

DOI https://dx.doi.org/10.2174/1570180814666170530094023	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X