PPARs在神经退行性和神经炎症通路中的作用

Title:PPARs in Neurodegenerative and Neuroinflammatory Pathways

Volume: 15 Issue: 4

关键词: 神经变性疾病，免疫系统，小胶质细胞，细胞因子，神经炎症，神经元

摘要: Background: PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content and has the higher energetic metabolism in the body.

Methods: In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a complicated relationship between the innate immune response and tissue metabolism.

Results: In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly involving glucose utilization and production, a condition which is generally related to metabolic changes.

Conclusion: Taking into account the high expression of PPARs in the brain, this review will focus on the role of these transcription factors in CNS diseases.

Cite this article as:

PPARs in Neurodegenerative and Neuroinflammatory Pathways, Current Alzheimer Research 2018; 15 (4) . https://dx.doi.org/10.2174/1567205014666170517150037