摘要
背景:当代神经生物学,牙周医学和免疫学正在关注慢性牙周炎与全身性疾病之间的关系,其中还包括阿尔茨海默病(AD)。 然而,痴呆与牙周炎之间的因果关系尚未确定。 目的:本研究的目的是确定牙周健康状况和认知能力是否与作为全身炎症的反映的促炎和抗炎细胞因子的系统测量的相对变化相关。我们假设牙周健康状况差可能与全身性炎症恶化的认知障碍和痴呆相关。 方法:根据从128名参与者分离的未刺激和LPS刺激的PBL产生的牙周和精神病学检查和细胞因子水平,我们检查了这两种临床描述的条件的共存是否可能对全身炎症有影响。 精神状态检查(MMSE)和检测出血检测结果(BoP)结合到一个数学函数U中,确定特定条件的严重程度,称为认知和牙周损伤状态。 类似地,细胞因子的水平被组合成一个数学函数V,其值决定了炎症状态的水平。确定U和V之间的相关性。 结果:这些结果证实认知衰退的存在和促炎介质的额外来源,如牙周健康问题,加剧了全身炎症。 结论:这两种疾病的并发症最有可能加深认知功能障碍和神经变性病变,并进一步发展为痴呆和AD。
关键词: BPSD,长期护理,痴呆症,过渡性护理单位,护理人员,神经心理学。
Current Alzheimer Research
Title:The Ultimate Outlier: Transitional Care for Persons with Dementia and BPSD
Volume: 14 Issue: 9
关键词: BPSD,长期护理,痴呆症,过渡性护理单位,护理人员,神经心理学。
摘要: Background: Transitional care units aim to assist caregivers who cannot manage the care for persons with dementia who manifest behavioral and psychological symptoms of dementia (BPSD). However, there is a dearth of research on such care units.
Objective: The current study reviewed one specialized transitional unit to better understand the characteristics of the persons with dementia and behavioral symptoms entering such unit. The study also looked at the change in terms of (a) BPSD, (b) use of psychotropic medications and (c) function of the patients in this unit. Method: A retrospective chart review of 73 residents of a transitional care unit was conducted. Background and outcome information were collected on electronic data entry sheets. Results: Patients had an average age of 75.0 years, 74.0% were men. Mean Cognitive Performance Scale score was 4.7. Comparing admission to discharge, there was a significant decrease in BPSD, and a significant increase in number of central nervous system medications. There were no significant changes in cognition or ability to perform activities of daily living. Conclusion: Patient characteristics differed from those of other long term care settings. This unique population requires further study to optimize the outcomes.Export Options
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Cite this article as:
The Ultimate Outlier: Transitional Care for Persons with Dementia and BPSD, Current Alzheimer Research 2017; 14 (9) . https://dx.doi.org/10.2174/1567205014666170515141710
DOI https://dx.doi.org/10.2174/1567205014666170515141710 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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