Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

Title:Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

Volume: 23 Issue: 41

Author(s): Maria Yanez, James Blanchette and Ehsan Jabbarzadeh*

Affiliation:

• Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208,United States

Keywords: Inflammatory response, biomaterials, angiogenesis, tissue engineering, macrophages, natural compounds.

Abstract: Tissue engineering offers a promising strategy to restore injuries resulting from trauma, infection, tumor resection, or other diseases. In spite of significant progress, the field faces a significant bottleneck; the critical need to understand and exploit the interdependencies of tissue healing, angiogenesis, and inflammation. Inherently, the balance of these interacting processes is affected by a number of injury site conditions that represent a departure from physiological environment, including reduced pH, increased concentration of free radicals, hypoglycemia, and hypoxia. Efforts to harness the potential of immune response as a therapeutic strategy to promote tissue repair have led to identification of natural compounds with significant anti-inflammatory properties. This article provides a concise review of the body’s inflammatory response to biomaterials and describes the role of oxygen as a physiological cue in this process. We proceed to highlight the potential of natural compounds to mediate inflammatory response and improve host-graft integration. Herein, we discuss the use of natural compounds to map signaling molecules and checkpoints that regulate the cross-linkage of immune response and skeletal repair.

Cite this article as:

Yanez Maria, Blanchette James and Jabbarzadeh Ehsan *, Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds, Current Pharmaceutical Design 2017; 23 (41) . https://dx.doi.org/10.2174/1381612823666170510124348