对赖氨酸特异性脱乙基酶1(LSD1)抑制剂筛选方法的综述

Title:An Overview on Screening Methods for Lysine Specific Demethylase 1 (LSD1) Inhibitors

Volume: 24 Issue: 23

关键词: LSD1，抑制剂，筛选模型，酶耦合分析，lc - ms，FRET

摘要: Background: In the past few years, great of attention has been paid to the identification and characterization of selective and potent inhibitors of the first identified histone demethylase LSD1, which may erase mono- and di-methylated histone 3 lysine 4 and 9. As the aberrant overexpression of LSD1 is involved in various pathological processes, especially cancer, obtaining selective and potent LSD1 inhibitors has emerged as a crucial issue in medicinal chemistry research.

Cite this article as:

An Overview on Screening Methods for Lysine Specific Demethylase 1 (LSD1) Inhibitors, Current Medicinal Chemistry 2017; 24 (23) . https://dx.doi.org/10.2174/0929867324666170509114321