摘要
背景:癌症是世界上死亡的主要原因之一。尚未有效治愈,对目前的化疗仍然是一大挑战。 目的:本综述总结了最新的关于可能的应用phytosome配合物在癌症治疗,他们的配方技术,通过phytosome运输机制的调查。 结果:纳米技术通过修改药物及其载体的重要性质开辟了癌症治疗的先驱领域。纳米技术利用各种纳米结构将抗癌剂运送到作用部位。纳米细胞体的更高的稳定性是由于磷脂分子和植物活性剂之间形成化学连接。在几种新的药物递送系统中,植脂体描绘了将植物活性化合物递送至目标作用部位的先进技术,目前,几种植物成分制剂正在临床使用。 结论:植物体配方可增强植物成分的潜在抗癌特性。
关键词: 癌症,药物递送,纳米载体,磷脂,phytosome,抗癌剂。
图形摘要
Current Drug Targets
Title:Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy
Volume: 19 Issue: 2
关键词: 癌症,药物递送,纳米载体,磷脂,phytosome,抗癌剂。
摘要: Background: Cancer is one of the main causes of death in the world. It has not yet been cured in an efficient manner and has remained a major challenge for current chemotherapy.
Objective: This review summarizes the latest investigations regarding the possible application of phytosome complexes for cancer therapy, their formulation techniques, and mechanism of transportation through phytosome.
Results: Nanotechnology opened a pioneer field in cancer therapy by modifying significant properties of drugs and their carriers. Nanotechnology utilizes various nanostructures to transport anti-cancer agents to the site of action. The greater stability of nanophytosomes is due to formation of chemical links between phospholipid molecules and phytoactive agents. Among several new drug delivery systems, phytosomes depict an advanced technology to deliver phytoactive compounds to the target site of action, and at present, several phytosome formulations are in clinical use.
Conclusion: Potential anti-cancer properties of phytoconstituents are enhanced by phytosomal formulations.
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Cite this article as:
Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy, Current Drug Targets 2018; 19 (2) . https://dx.doi.org/10.2174/1389450118666170508095250
DOI https://dx.doi.org/10.2174/1389450118666170508095250 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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