摘要
背景:现在有大量证据表明脂质代谢在包括阿尔茨海默氏病在内的许多神经退行性疾病中受到影响。这些功能障碍导致脑,脑脊液和血浆中的某些脂质水平异常。因此在神经退行性疾病中建立血脂谱是有意义的。这种方法可以有助于鉴定阿尔茨海默病的脂质生物标志物,也可以确定新的治疗靶点。因此有兴趣集中于阿尔茨海默病中的中心和外周生物标志物。 方法:对148篇论文的文献进行回顾。基于这些文献,已经提出脂质(胆固醇和氧固醇,脂肪酸,磷脂)参与阿尔茨海默氏病。 结果:在脂质生物标记物引用的阿尔茨海默病148篇参考文献中,65指胆固醇和氧固醇,35指脂肪酸,40指磷脂。在这些脂质中,其中一些如24S-羟基胆固醇,尤其在基因治疗中开辟了新的治疗视角。长链脂肪酸的结果表明过氧化物酶体功能障碍在阿尔茨海默病中的潜力。至于磷脂,它们可以构成用于在前驱阶段检测疾病的有趣的生物标志物。 结论:现在有几条证据表明脂质在AD的发病机制中发挥重要作用,其中一些具有预后和诊断价值。这可能为确定新的治疗靶点,新的有效药物和/或新疗法铺平道路。
关键词: 阿尔茨海默病,生物标记物,脂质,胆固醇,氧固醇,脂肪酸,磷脂
Current Alzheimer Research
Title:Lipid Biomarkers in Alzheimer's Disease
Volume: 15 Issue: 4
关键词: 阿尔茨海默病,生物标记物,脂质,胆固醇,氧固醇,脂肪酸,磷脂
摘要: Background: There are now significant evidences that lipid metabolism is affected in numerous neurodegenerative diseases including Alzheimer’s disease. These dysfunctions lead to abnormal levels of certain lipids in the brain, cerebrospinal fluid and plasma. It is consequently of interest to establish lipid profiles in neurodegenerative diseases. This approach, which can contribute to identify lipid biomarkers of Alzheimers' disease, can also permit to identify new therapeutic targets. It was therefore of interest to focus on central and peripheral biomarkers in Alzheimer's disease.
Methods: A review of the literature on 148 papers was conducted. Based on this literature, the involvement of lipids (cholesterol and oxysterols, fatty acids, phospholipids) in Alzheimer's disease has been proposed.
Results: Of the 148 references cited for lipid biomarkers for Alzheimer's disease, 65 refer to cholesterol and oxysterols, 35 to fatty acids and 40 to phospholipids. Among these lipids, some of them such as 24S-hydroxyckolesterol, open up new therapeutic perspectives in gene therapy, in particular. The results on the very long-chain fatty acids suggest the potential of peroxisomal dysfunctions in Alzheimer's disease. As for the phospholipids, they could constitute interesting biomarkers for detecting the disease at the prodromal stage.
Conclusion: There are now several lines of evidence that lipids play fundamental roles in the pathogenesis of AD and that some of them have a prognostic and diagnosis value. This may pave the way for the identification of new therapeutic targets, new effective drugs and / or new treatments.
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Cite this article as:
Lipid Biomarkers in Alzheimer's Disease, Current Alzheimer Research 2018; 15 (4) . https://dx.doi.org/10.2174/1567205014666170505101426
DOI https://dx.doi.org/10.2174/1567205014666170505101426 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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