Recent Advances in Cu-catalyzed Click Reaction and Its Applications

Title:Recent Advances in Cu-catalyzed Click Reaction and Its Applications

Volume: 21 Issue: 22

Author(s): Zhou Zhao, Zonghui Yao and Xiaowei Xu*

Affiliation:

• State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu 210009,China

Keywords: Click reaction, copper catalysis, cycloaddition, bioorthogonal chemistry, applications, detection.

Abstract: Background: Cu-catalyzed azide–alkyne cycloaddition (CuAAC), as the most exemplary click reaction, plays an important role in attaching a probe or substrate of interest to a specific bio-macromolecule or small molecule. So CuAAC has attracted many chemists and biologists interest.

Objective: Click reaction provides a powerful tool to solve tremendous questions in chemical biology. Using CuAAC, chemists and biologists dug into plentiful chemical and biological problems.

Conclusion: This review focuses on the CuAAC and its recent applications in different fields. The applications of CuAAC are dispersing to the field of detecting hydrazoic acids, fluoride ions, and labeling proteins, nucleic acids or other biological molecules and even in material science. Both in small molecular and biological macromolecular detection, CuAAC plays an important role and provides a lot of methods to investigate biological processes. The promoted CuAAC reaction is studied well and the applications of CuAAC in solid phase synthesis are described. In addition, more applications of CuAAC can be developed.

Cite this article as:

Zhao Zhou , Yao Zonghui and Xu Xiaowei *, Recent Advances in Cu-catalyzed Click Reaction and Its Applications, Current Organic Chemistry 2017; 21 (22) . https://dx.doi.org/10.2174/1385272821666170503105607