Pharmacophore Discovery - Lessons Learned

Title: Pharmacophore Discovery - Lessons Learned

Volume: 9 Issue: 20

Author(s): John H. van Drie

Affiliation:

Keywords: pharmacophores

Abstract: Pharmacophore discovery is one of the major elements of molecular modeling in the absence of X-ray structural data. While pharmacophores initially made their debut as a means for lead discovery, more recent refinements have brought them into the domain of lead optimization, e.g. as a means to define the molecular alignment in 3D-QSAR. In this review, the experiences of over a decade of confronting and solving the challenges of pharmacophore discovery applied to actual drug discovery are summarized. Also, practical tips are described for using the authors methodology for pharmacophore discovery, DANTE..

Cite this article as:

van Drie H. John, Pharmacophore Discovery - Lessons Learned, Current Pharmaceutical Design 2003; 9 (20) . https://dx.doi.org/10.2174/1381612033454568