摘要
癌症是一个全球性的健康问题,它损害了患者的生活质量,每年在全世界造成数千人死亡。前列腺六跨膜上皮抗原(STEAP 1)的鉴定ED在几种癌症,即前列腺癌(PCA)中过度表达。考虑到它的二级结构,以及它在细胞膜中的位置,有人建议它扮演一个角色i。肿瘤细胞间的细胞间通讯。考虑到STEAP 1在人类癌症中的高特异性和高表达,STEAP 1是目前应用于临床的一种很有前途的治疗方法。c目标。在过去的几年里,针对STEAP 1的一些策略已经被开发出来,包括抗体-药物结合物,单克隆抗体(MAb),dna疫苗和小的非编码RNAs。(NcRNA)。本文就STEAP 1蛋白在人体组织中的表达、生物化学特性及靶向策略等方面的研究进展作一综述,以评价STEAP 1蛋白在人体组织中的表达潜力癌症的治疗剂。
关键词: STEAP 1,癌症,DNA疫苗,单克隆抗体,小非编码RNA,前列腺癌。
图形摘要
Current Cancer Drug Targets
Title:Targeting STEAP1 Protein in Human Cancer: Current Trends and Future Challenges
Volume: 18 Issue: 3
关键词: STEAP 1,癌症,DNA疫苗,单克隆抗体,小非编码RNA,前列腺癌。
摘要: Cancer is a global health issue that impairs the life quality of patients and origins thousands of deaths annually worldwide. Six-transmembrane epithelial antigen of the prostate (STEAP1) was identified to be overexpressed in several types of cancers, namely in prostate cancer (PCa). Considering its secondary structure, associated with its location in the cell membrane, has been suggested a role in intercellular communication between tumour cells. Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target. Several strategies have been developed during the last few years for targeting STEAP1, including antibody-drug conjugates, monoclonal antibodies (mAbs), DNA vaccines and small noncoding RNAs (ncRNAs). This review presents the current knowledge about STEAP1 protein expression in human tissues, its biochemical properties and targeting strategies with the purpose to evaluate its potential as therapeutic agent for cancer.
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Targeting STEAP1 Protein in Human Cancer: Current Trends and Future Challenges, Current Cancer Drug Targets 2018; 18 (3) . https://dx.doi.org/10.2174/1568009617666170427103732
DOI https://dx.doi.org/10.2174/1568009617666170427103732 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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