Characterization of a Novel Polysaccharide-Iron(III) Complex and Its Anti-Anemia and Nonspecific Immune Regulating Activities

Title:Characterization of a Novel Polysaccharide-Iron(III) Complex and Its Anti-Anemia and Nonspecific Immune Regulating Activities

Volume: 17 Issue: 17

Author(s): Yun Zhang, Fanyi Ma, Jinhua Zhu, Zuliang Du, Ying-Yong Zhao and Xiuhua Liu*

Affiliation:

• Key Lab. of Natural Medicine and Immune-Engineering of Henan Province College of Chemistry and Chemical Engineering Henan University, Kaifeng, 475004,China

Keywords: Dioscorea opposita Thunb, iron deficiency anemia, iron supplement, polysaccharide, polysaccharide-iron(III) complex.

Abstract: Objective: Dioscorea opposita Thunb is the famous food and traditional medicine in China and it was rich in polysaccharides. Polysaccharides of Dioscorea Opposita Thunb possess immunoregulatory activity, free radical scavenging activity and anti-diabetic activity. A novel polysaccharide- iron(III) complex (CYPIC) was synthesized by using crude polysaccharide extracted from Dioscorea opposita Thunb. The component, structure, morphology and molecular weights of CYPIC were analysed, and the anti-anemia, acute toxicity and nonspecific immune regulating activities of CYPIC were assayed. The results showed that CYPIC could increase red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT), thymus and spleen index of mice with iron deficiency anemia (IDA). Although the structure and deeper mechanisms of CYPIC should be further studied, CYPIC has the potential to be used as an iron supplement for the treatment of iron deficiency anemia.

Conclusion: The large scale industrial production was suggested due to the simple preparation processing of CYPIC.

Cite this article as:

Zhang Yun , Ma Fanyi , Zhu Jinhua , Du Zuliang , Zhao Ying-Yong and Liu Xiuhua*, Characterization of a Novel Polysaccharide-Iron(III) Complex and Its Anti-Anemia and Nonspecific Immune Regulating Activities, Mini-Reviews in Medicinal Chemistry 2017; 17 (17) . https://dx.doi.org/10.2174/1389557517666170424130327