摘要
纳米医学是最近的一个有希望的环境,为目前的医学治疗,特别是癌症的进展。纳米粒子介导的疗法旨在解决极其复杂的现象,涉及不同的生化、机械和生物物理因素。通过帮助理解生物机制和提供定量分析,计算模型可以帮助医学研究。在这项工作中,我们报告了与纳米粒子在抗癌治疗中的应用有关的四个主要问题的计算模型,即纳米粒子的传递、细胞对纳米粒子的吸收、纳米平台药物的释放以及纳米粒子的治疗。在硅方法是一个有价值的工具,以帮助临床研究,指导新的纳米粒子配方的合理设计,并确定现有治疗的最佳策略。
关键词: 纳米粒子,纳米粒子的传递,吸收,药物释放,治疗效果,数学和计算模型。
Current Medicinal Chemistry
Title:In Silico Models for Nanomedicine: Recent Developments
Volume: 25 Issue: 34
关键词: 纳米粒子,纳米粒子的传递,吸收,药物释放,治疗效果,数学和计算模型。
摘要: Nanomedicine is a recent promising setting for the advancement of current medical therapies, in particular for cancer. Nanoparticle-mediated therapies are aimed to tackle extremely complex phenomena, involving different biochemical, mechanical and biophysical factors. Computational models can contribute to medical research by helping the understanding of biological mechanisms and by providing quantitative analyses. In this work, we report on computational models that address four main issues related to the use of nanoparticles in anti-cancer therapies, namely the delivery of nanoparticles, their uptake by cells, the release of drugs from nano-platforms and nanoparticle-based therapeutics. In silico approaches constitute a valuable tool to aid clinical studies, to guide the rational design of new nanoparticle formulations and to identify the optimal strategies for existing treatments.
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Cite this article as:
In Silico Models for Nanomedicine: Recent Developments, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867324666170417120725
DOI https://dx.doi.org/10.2174/0929867324666170417120725 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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