摘要
背景:阿尔茨海默氏痴呆的特征是皮层和皮层下的明显萎缩,导致不同的神经心理学缺陷。根据体细胞标记假设,负责产生体细胞标记的区域可以预测决策的后果,从而优化过程,这些患者将受到影响。 目的:本实验的目的是研究阿尔茨海默型痴呆患者的决策过程,以确定由于该疾病导致的这些过程中的潜在缺陷,除了老化典型的认知障碍之外。此外,我们还希望根据前景价格学习参数确定这些患者的决策特征。 方法:我们评估了30名阿尔茨海默病患者和30名健康受试者的对照组。爱荷华州赌博任务的简短版本被使用。 结果:结果显示,患者的选择不如对照。组间差异是定量和定性的,因为观察到的价格学习决策中认定机制的显着差异。这些结果与神经影像学研究的证据以及遗忘患者的工作一致。 结论:我们的病人决策中的问题可能是由于这种疾病的特征性记忆缺陷,这阻碍了他们建立新的刺激 - 奖励关系,并且由于它们出现的顶叶和颞叶萎缩而消除以前学到的反应。
关键词: 轻度阿尔茨海默痴呆,决策,前景价态学习,体征标记假说,软件推车,记忆力减退。
Current Alzheimer Research
Title:Cognitive Mechanisms in Decision-Making in Patients With Mild Alzheimer Disease
Volume: 14 Issue: 12
关键词: 轻度阿尔茨海默痴呆,决策,前景价态学习,体征标记假说,软件推车,记忆力减退。
摘要: Background: Alzheimer's dementia is characterized by significant cortical and subcortical atrophy, causing diverse neuropsychological deficits. According to the somatic marker hypothesis, the areas responsible for generating the somatic markers that anticipate the consequences of a decision and thereby optimize the process would be affected in these patients.
Objective: The aim of this experiment is to study the decision-making processes in Alzheimer type dementia patients to determine potential deficits in these processes as a result of the disease, aside from the cognitive impairment that is typical of aging. In addition, we wish to determine the defining characteristics of decision-making in these patients, on the basis of the prospect valence-learning parameters.
Method: We evaluated 30 patients with Alzheimer's disease and a control group of 30 healthy subjects. A short version of the Iowa Gambling Task was used.
Results: The results showed that patients made less advantageous choices than did controls. Group differences were quantitative and qualitative, as significant differences in cognitive mechanisms identified in the prospect valence-learning decisions were observed. These results are consistent with evidence from neuroimaging studies as well as with work carried out with amnesic patients.
Conclusion: That problems in our patients' decision-making could be due to the characteristic memory deficits of this disease, which prevents them from establishing new stimulus-reward relationships and eliminating previously learned responses as a result of the parietal and temporal atrophy they present.
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Cite this article as:
Cognitive Mechanisms in Decision-Making in Patients With Mild Alzheimer Disease, Current Alzheimer Research 2017; 14 (12) . https://dx.doi.org/10.2174/1567205014666170417113834
DOI https://dx.doi.org/10.2174/1567205014666170417113834 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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