摘要
背景:纳米团簇由几个到几十个原子组成,尺寸小于2 nm。与纳米粒子相比,它们表现出优异的性能,例如荧光可调,易接合,高量子产率和生物相容性,这在癌症纳米治疗学的发展中是非常需要的。因此,金属纳米团簇已经成为癌症纳米药物的新成员。这篇综述旨在总结最近开发的制备金属纳米团簇的方法,强调其在癌症诊断学中的应用,并为纳米医学纳米团簇的未来发展提供简要展望。 方法:我们使用在线数据库进行了彻底的文献检索。搜索集中在一个中心问题上。不相关的文章在进一步检查后被排除在外,直接相关的文章被包括在内。相关文章按主题分类,综合这些文章的信息。 结果:本评价纳入143篇文章。大约八十篇文章概述了纳米团簇合成方法的发展。合成方法包括化学还原,光还原等。分别在十五篇和八篇文章中描述了将金纳米簇和银纳米簇应用于癌症治疗学的进展。其余的文章是关于使用其他金属纳米簇和纳米簇纳米复合材料作为癌症治疗剂的进展。 结论:本综述总结了金属纳米簇或其纳米复合材料作为癌症治疗剂的合成和应用。它证实了它们作为诊所新一代癌症疗法的重要性,优势和潜力。
关键词: 金属纳米簇,癌症诊断,癌症成像,成像试剂,癌症诊断,纳米医学。
Current Medicinal Chemistry
Title:Metallic Nanoclusters for Cancer Imaging and Therapy
Volume: 25 Issue: 12
关键词: 金属纳米簇,癌症诊断,癌症成像,成像试剂,癌症诊断,纳米医学。
摘要: Background: Nanoclusters are made of a few to tens of atoms with a size below 2 nm. Compared with nanoparticles, they exhibited excellent properties, such as tunable fluorescence, ease of conjugation, high quantum yield and biocompatibility, which are highly desired in the development of cancer nanotheranostics. Hence, the metallic nanoclusters have emerged as a newcomer in cancer nanomedicines. This review aims to summarize recently developed approaches to preparing metallic nanoclusters, highlight their applications in cancer theranostics, and provide a brief outlook for the future developments of nanoclusters in nanomedicine.
Method: We carried out a thorough literature search using online databases. The search was focused on a centered question. Irrelevant articles were excluded after further examination and directly relevant articles were included. The relevant articles were classified by the subjects and the information from these articles was synthesized.
Results: One hundred and forty-three articles were included in this review. About eighty articles outlined the development in the synthetic methods of nanoclusters. The synthesis approaches include chemical reduction, photoreduction and so on. The progress in the application of gold and silver nanoclusters to cancer theranostics was described in fifteen and eight articles, respectively. The rest articles were about the advancements in the use of other metal nanoclusters and nanocluster nanocomposites as cancer theranostic agents.
Conclusion: This review summarizes the synthesis and use of metallic nanoclusters or their nanocomposites as cancer theranostic agents. It confirms their importance, advantages and potentials in serving as a new generation of cancer theranostics in clinics.
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Cite this article as:
Metallic Nanoclusters for Cancer Imaging and Therapy, Current Medicinal Chemistry 2018; 25 (12) . https://dx.doi.org/10.2174/0929867324666170331122757
DOI https://dx.doi.org/10.2174/0929867324666170331122757 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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