摘要
背景:近年来,针对一系列人类疾病的金牌药物的研究已经复苏。本文回顾了黄金产品在人类病理学不同领域的最重要的应用。 Au(I)和Au(III)化合物已经在临床实践中被重新引入,用于靶向涉及病毒和寄生虫病,类风湿性关节炎和癌症的发生和进展的细胞成分。 结果:经过一些简要的历史记录,本文考虑了金化合物对结核分枝杆菌的应用,以及在结核病和类风湿性关节炎治疗中的应用。然后考虑使用含黄金的药物治疗癌症,特别强调使用纳米颗粒和光热疗法。最近十年介绍的胶体金在诊断中的应用已经被广泛讨论。作为最后一点,介绍了在医学中使用的各种黄金衍生物的不利影响和毒性的调查。 结论:在这篇综述中,我们描述了黄金在诊断学和治疗多种人类疾病(从退行性疾病到传染性疾病到癌症)方面的广泛应用。特别是金纳米粒子在现代临床医学中显示出吸引人的元素,结合了高治疗特性,高选择性靶向癌细胞和低毒性。
关键词: 金,纳米颗粒,胶体金,类风湿性关节炎,结核,癌症,诊断,毒性作用。
Current Medicinal Chemistry
Title:Gold - Old Drug with New Potentials
Volume: 25 Issue: 1
关键词: 金,纳米颗粒,胶体金,类风湿性关节炎,结核,癌症,诊断,毒性作用。
摘要: Background: Research into gold-based drugs for a range of human diseases has seen a revival in recent years. This article reviews the most important applications of gold products in different fields of human pathology. Au(I) and Au(III) compounds have been re-introduced in clinical practice for targeting the cellular components involved in the onset and progression of viral and parasitic diseases, rheumatoid arthritis and cancer.
Results: After some brief historical notes, this article takes into account the applications of gold compounds against Mycobacterium tuberculosis, and also in tuberculosis and in rheumatoid arthritis treatment. The use of gold containing drugs in the cure of cancer are then considered, with special emphasis to the use of nanoparticles and to the photo-thermal cancer therapy. The use of colloidal gold in diagnostics, introduced in the last decade is widely discussed. As a last point a survey on the adverse effects and on the toxicity of the various gold derivatives in use in medicine is presented.
Conclusion: In this review, we described the surprisingly broad spectrum of possible uses of gold in diagnostics and in therapeutic approaches to multiple human diseases, ranging from degenerative to infectious diseases, and to cancer. In particular, gold nanoparticles appear as attractive elements in modern clinical medicine, combining high therapeutic properties, high selectivity in targeting cancer cells and low toxicity.
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Gold - Old Drug with New Potentials, Current Medicinal Chemistry 2018; 25 (1) . https://dx.doi.org/10.2174/0929867324666170330091438
DOI https://dx.doi.org/10.2174/0929867324666170330091438 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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