摘要
背景：血管内皮生长因子（VEGF）是一种能促进大脑神经发生和血管生成的神经保护性细胞因子。 在动物模型中，已经表明，环境富集和运动，有利于减少阿尔茨海默病（AD）进展和抑郁样行为的两种非药物干预增强海马VEGF表达和神经发生。 此外，VEGF表达的刺激促进神经传递和突触可塑性过程如神经发生。 据认为，这些VEGF在脑中的作用可能对精神病学和其他神经病症有很大的有益的治疗作用。 结论：在本次回顾中，讨论了VEGF缺陷与AD发展的关联以及VEGF信号传导作为可替宁治疗靶标和其他干预措施在神经退行性疾病中的潜在作用。
关键词: VEGF，阿尔茨海默病，肌萎缩性侧索硬化，可替宁，烟碱受体，抑郁症，烟草，血管发生，痴呆，神经变性。
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