摘要
背景:干细胞治疗为各种神经疾病提供了很有前途的治疗益处。细胞移植已经成为神经损伤的细胞替代应用。近年来,纳米材料在各种工业和医学领域得到了广泛的发展,纳米粒子已被应用于神经系统疾病跟踪治疗领域。干细胞与纳米技术的结合越来越受到关注;证明该组合对多种中枢神经系统疾病的临床诊断和治疗具有重大影响,同时改善预后。 目的:本文旨在简要介绍纳米材料在干细胞治疗神经系统疾病中的应用。 结果:纳米颗粒不仅在体外或体内促进干细胞增殖和分化,而且在干细胞成像和追踪中发挥主导作用。此外,通过递送基因或药物,纳米颗粒可以参与干细胞治疗各种神经疾病如缺血性中风,脊髓损伤(SCI),多发性硬化症(MS),帕金森病(PD),阿尔茨海默病(AD)和神经胶质瘤。然而,纳米粒子对神经细胞具有潜在的细胞毒性作用,这与它们的物理化学性质有关。 结论:基于纳米干细胞的治疗作为一种有前景的策略有能力影响中枢神经系统的神经元修复和再生。
关键词: 干细胞,纳米颗粒,中枢神经系统疾病,神经发生,跟踪,细胞移植。
图形摘要
Current Drug Targets
Title:The Application of Nanomaterials in Stem Cell Therapy for Some Neurological Diseases
Volume: 19 Issue: 3
关键词: 干细胞,纳米颗粒,中枢神经系统疾病,神经发生,跟踪,细胞移植。
摘要: Background: Stem cell therapy provides great promising therapeutic benefits for various neurological disorders. Cell transplantation has emerged as cell replacement application for nerve damage. Recently, nanomaterials obtain wide development in various industrial and medical fields, and nanoparticles have been applied in the neurological field for tracking and treating nervous system diseases. Combining stem cells with nanotechnology has raised more and more attentions; and it has demonstrated that the combination has huge effects on clinical diagnosis and therapeutics in multiple central nervous system diseases, meanwhile, improves prognosis.
Objective: The aim of this review was to give a brief overview of the application of nanomaterials in stem cell therapy for neurological diseases.
Results: Nanoparticles not only promote stem cell proliferation and differentiation in vitro or in vivo, but also play dominant roles on stem cell imaging and tracking. Furthermore, via delivering genes or drugs, nanoparticles can participate in stem cell therapeutic applications for various neurological diseases, such as ischemic stroke, spinal cord injury (SCI), multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD) and gliomas. However, nanoparticles have potential cytotoxic effects on nerve cells, which are related to their physicochemical properties.
Conclusion: Nano-stem cell-based therapy as a promising strategy has the ability to affect neuronal repair and regeneration in the central nervous system.
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Cite this article as:
The Application of Nanomaterials in Stem Cell Therapy for Some Neurological Diseases, Current Drug Targets 2018; 19 (3) . https://dx.doi.org/10.2174/1389450118666170328115801
DOI https://dx.doi.org/10.2174/1389450118666170328115801 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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