摘要
背景:癌症治疗的目标之一是症状管理,特别是在末期。癌症的常见症状包括疼痛,疲劳,抑郁和认知功能障碍。症状管理的可用治疗选择有限。哌甲酯是一种精神兴奋剂,可能对这些患者有益。在这份报告中,我们回顾了使用哌甲酯治疗癌症患者的症状。 方法:在PubMed上进行电子文献检索,使用以下关键词:哌甲酯,癌症,癌症,肿瘤学,肿瘤学和肿瘤。我们确定了42篇有关使用哌甲酯治疗癌症患者的相关研究和出版物,并将其纳入本文。 结果:发现哌甲酯具有减少癌症患者中阿片样物质诱导镇静,改善认知症状和减轻疲劳的一些证据。然而,由于研究人群的差异,研究设计和结果测量等因素,结果并不一致。关于其用于治疗抑郁症的证据极少。否则,哌甲酯一般对患者耐受良好。 结论:本综述有可能支持使用哌甲酯治疗阿片类药物引起的镇静,认知能力下降和癌症患者疲劳。进一步的安慰剂对照试验将有助于加强这种治疗的证据。
关键词: 哌甲酯,癌症,疲劳,抑郁,认知,疼痛。
图形摘要
Current Drug Targets
Title:The Use of Methylphenidate for Physical and Psychological Symptoms in Cancer Patients: A Review
Volume: 19 Issue: 8
关键词: 哌甲酯,癌症,疲劳,抑郁,认知,疼痛。
摘要: Background: One of the goals of cancer treatment is symptoms management especially at the end stage. The common symptoms in cancer include pain, fatigue, depression and cognitive dysfunction. The available treatment options for symptom management are limited. Methylphenidate, a psychostimulant, may be of benefit for these patients. In this report, we review the use of methylphenidate for symptoms control in cancer patients.
Method: Electronic literature search on PubMed was conducted using the following keywords: methylphenidate, cancer, carcinoma, oncology, oncological and tumour. We identified forty two relevant studies and publications on the use of methylphenidate in cancer patients to be included in this review.
Results: Methylphenidate was found to have some evidence in reducing opioid-induced sedation, improving cognitive symptoms and reduction of fatigue in cancer patients. Nevertheless, the results were inconsistent due to variations in the study populations, study design and outcome measures, among others. There was minimal evidence on its use in treating depression. Otherwise, methylphenidate was generally well-tolerated by patients.
Conclusion: This review potentially supports the use of methylphenidate for opioid-induced sedation, cognitive decline and fatigue in cancer patients. Further placebo-controlled trials would help in strengthening the evidence for this treatment.
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Cite this article as:
The Use of Methylphenidate for Physical and Psychological Symptoms in Cancer Patients: A Review, Current Drug Targets 2018; 19 (8) . https://dx.doi.org/10.2174/1389450118666170317162603
DOI https://dx.doi.org/10.2174/1389450118666170317162603 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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