摘要
背景:金纳米颗粒(AuNPs)在医学领域的成像,诊断和治疗中具有巨大的应用潜力。 AuNPs以其局部表面等离子体共振(LSPR)性质,较大的表面积和与体液的生物相容性而闻名。此外,AuNPs在癌症治疗的新方法中已经占据突出地位,如光热和成像治疗。虽然AuNPs在医疗领域具有巨大的应用潜力,但是在生理条件下它们的不稳定性阻止了进一步的使用。然而,通过将AuNP与生物聚合物结合可以克服这个限制。据我们所知,在医疗领域合理化AuNP多糖复合材料的结构/性质关系和应用的修订文件尚未公布。 方法:本手稿讨论了基于绿色化学的AuNP合成的最相关方面和最先进的概念,以及与多糖的结合,可以有效地起到Au纳米颗粒的稳定剂和还原剂的作用。更多的是,多糖装置可以抑制AuNP和生物大分子之间的非特异性相互作用,抑制AuNP表面上不合适的“蛋白质电晕”结构,从而增加用作药物递送基质和伤口愈合装置的AuNP复合材料的潜力,以及用于癌症治疗和生物传感器的光热/成像目的。
关键词: 金纳米颗粒,多糖,复合材料,光热疗法,生物传感器,医学成像,药物递送,组织工程
Current Medicinal Chemistry
Title:Polysaccharide-Based Materials Associated with or Coordinated to Gold Nanoparticles: Synthesis and Medical Application
Volume: 24 Issue: 25
关键词: 金纳米颗粒,多糖,复合材料,光热疗法,生物传感器,医学成像,药物递送,组织工程
摘要: Background: Gold nanoparticles (AuNPs) have enormous potential for application in imaging, diagnosis, and therapies in the medical field. AuNPs are renowned for their localized surface plasmon resonance (LSPR) properties, large surface area, and biocompatibility with body fluids. Further, AuNPs have featured prominently in new methodologies for cancer treatments, like photothermal and imaging therapies. Although AuNPs present enormous potential for application in the medical field, their instability under physiological conditions prevents further uses. However, this limitation may be overcome by associating AuNPs with biopolymers. To the best of our knowledge, a revision paper rationalizing the structure/property relationship and applications of AuNPspolysaccharide composites in the medical field has not been published yet.
Methods: This manuscript discusses the most relevant aspects and state-of-art concepts surrounding the synthesis of AuNPs based on green chemistry and their association with polysaccharides that can efficiently function both as stabilizing and reducing agents of Au nanoparticles. Even more, polysaccharide devices may inhibit non-specific interactions between AuNPs and biological macromolecules, suppressing unsuitable “protein corona” formations on AuNP surfaces, thereby increasing the potential of AuNP composites of being employing as drug delivery matrices and wound-healing devices as well as in photothermal/ imaging purposes for cancer treatments and biosensors.Export Options
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Cite this article as:
Polysaccharide-Based Materials Associated with or Coordinated to Gold Nanoparticles: Synthesis and Medical Application, Current Medicinal Chemistry 2017; 24 (25) . https://dx.doi.org/10.2174/0929867324666170309123351
DOI https://dx.doi.org/10.2174/0929867324666170309123351 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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