摘要
目的:本研究调查了视网膜小动脉中心反射(CR,视网膜血管照片中观察到的中心反射),由于这些血管网络之间的同源性,所以可以提供视网膜和大脑中的微血管健康信息。该研究还描述了一种新型的基于计算机的半自动化技术,可精确量化视网膜小动脉CR和血管宽度,并从数字视网膜照片中计算CR与血管宽度比(CRR)。 方法:在澳大利亚,从成像,生物标志和生活习惯研究(AIBL)参与者并收集数字视网膜照片,其中包括25名诊断为阿尔茨海默病(AD)(年龄72.4±7.5岁,12名男性,13名女性)和123名无痴呆症老年人(认知正常:CN)(年龄71.6±5.6岁,男性55岁,女性68岁)。使用144人的组群(22 AD,122 CN)与新CRR测量相比,我们确定了AD参与者的CRR水平(平均CRR 0.253(SD 0.04))显着高于CN(平均CRR 0.231(SD 0.04) ,p = 0.025)。APOEε4等位基因状态的调整降低了显着性(p = 0.081)。 与非载体相比,APOEε4等位基因携带者的CRR明显高于平均CRR 0.254(SD 0.03)(平均CRR为0.224(SD 0.05),p <0.0001)。 结果:这些数据表明,CRR与APOEε4状态密切相关,AD诊断呈现较弱的独立趋势。 视网膜可用作非侵入性监测APOEε4对中枢神经系统,特别是脑血管疾病的影响的新型模型。
关键词: 阿尔茨海默病,视网膜,视力障碍,老化,诊断,APOE。
Current Alzheimer Research
Title:Modulation of Retinal Arteriolar Central Reflection by APOE Genotype
Volume: 14 Issue: 9
关键词: 阿尔茨海默病,视网膜,视力障碍,老化,诊断,APOE。
摘要: Objective: This study investigated the retinal arteriolar central reflex (CR, the central reflection observed in photographs of retinal vessels), which may provide information about micro-vascular health in the retina and also the brain, due to the homology between these vascular networks. The study also describes a novel computer based semi-automated technique that accurately quantifies retinal arteriolar CR and vessel width, and calculates the CR to vessel width ratio (CRR) from digital retinal photographs.
Methods: Digital retinal photographs were collected from participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL), including 25 participants diagnosed with Alzheimer’s disease (AD) (age 72.4 ± 7.5 yrs, 12 male, 13 female) and 123 elderly participants without dementia (cognitively normals: CN) (age 71.6 ± 5.6 yrs, 55 male, 68 female). Using a sub-cohort of 144 (22 AD, 122 CN) with the novel CRR measures, we identified significantly higher CRR levels in AD participants (mean CRR 0.253 (SD 0.04)) as compared with CN’s (mean CRR 0.231 (SD 0.04), p = 0.025). Adjustment for APOE ε4 allele status however, reduced the significance (p = 0.081). CRR was significantly higher in APOE ε4 allele carriers (mean CRR 0.254 (SD 0.03) as compared with non-carriers (mean CRR 0.224 (SD 0.05), p < 0.0001). Results: These data indicate that CRR is strongly linked to APOE ε4 status and exhibits a weaker, independent trend with AD diagnosis. The retina may be useful as a novel model for non-invasive monitoring of the effects of APOE ε4 on the central nervous system, particularly in cerebrovascular disease.Export Options
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Cite this article as:
Modulation of Retinal Arteriolar Central Reflection by APOE Genotype, Current Alzheimer Research 2017; 14 (9) . https://dx.doi.org/10.2174/1567205014666170309115016
DOI https://dx.doi.org/10.2174/1567205014666170309115016 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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