摘要
包括天然存在的野生型病毒/减毒病毒和遗传修饰病毒的溶瘤病毒最近已经被开发用于创新的癌症治疗。 转基因的溶瘤病毒具有作为独特的基因治疗产品有条件复制的独特能力。 由于溶瘤病毒在患者中表现出延长的持久性,所以临床试验中的病毒脱落和传播给第三方应是临床试验的主要关注以及临床安全性和有效性。 因此,目前正在研究建立溶瘤病毒的安全性和有效性。
关键词: 溶瘤病毒,基因治疗,癌症治疗,复制病毒,基因修饰病毒,临床安全性和有效性。
图形摘要
Current Cancer Drug Targets
Title:Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies
Volume: 18 Issue: 2
关键词: 溶瘤病毒,基因治疗,癌症治疗,复制病毒,基因修饰病毒,临床安全性和有效性。
摘要: Oncolytic viruses, which include both naturally occurring wild-type viruses/attenuated viruses and genetically modified viruses, have recently been developed for use in innovative cancer therapies. Genetically modified oncolytic viruses possess the unique ability to replicate conditionally as a unique gene therapy product. Since oncolytic viruses exhibit prolonged persistence in patients, viral shedding and transmission to third parties should be major concerns for clinical trials along with the clinical safety and efficacy. Accordingly, studies are now underway to establish the safety and efficacy of oncolytic viruses.
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Cite this article as:
Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies, Current Cancer Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1568009617666170222142650
DOI https://dx.doi.org/10.2174/1568009617666170222142650 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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