广告介导的抗癌联合治疗的出现：期待什么？

Title:Emergence of Ad-Mediated Combination Therapy Against Cancer: What to Expect?

Volume: 18 Issue: 2

关键词: 联合治疗，腺病毒，溶瘤腺病毒，化疗，癌症，免疫治疗，放疗。

摘要: Novel treatment modalities are rapidly advancing toward clinical use as many malignant cancers still remain incurable. Adenovirus (Ad) in particular has been extensively researched as a promising alternative to conventional cancer therapy in the past decades. Although Ad has demonstrated promising therapeutic outcome and cancer specificity in preclinical models, its therapeutic efficacy in clinical trials is still insufficient due to several drawbacks such as rapid clearance of viral particles by host immune response, induction of acute inflammatory response, and hepatotoxicity. In this regard, combination of Ad with other cancer treatment modalities, such as chemotherapy, radiotherapy, or immunotherapy, can be an effective strategy to overcome the limitations of Ad. Cancerspecific and effective expression of multifunctional therapeutic genes by Ad can enhance the therapeutic profile of other treatment modalities, making it a logical candidate for combination therapy to combat malignant tumors.

Cite this article as:

Emergence of Ad-Mediated Combination Therapy Against Cancer: What to Expect?, Current Cancer Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1568009617666170222123406