Effect of Cinnamomum cassia on the Pharmacokinetics and Pharmacodynamics of Pioglitazone

Title:Effect of Cinnamomum cassia on the Pharmacokinetics and Pharmacodynamics of Pioglitazone

Volume: 12 Issue: 1

Author(s): Sandhya Mamindla, Venkata S.R.G.P. Koganti, Nagaraju Ravouru and Bharathi Koganti*

Affiliation:

• Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh 517502,India

Keywords: Diabetes mellitus, cinnamon bark powder, pioglitazone, HPLC analysis, CYP 3A4, glucose levels, GOD/POD.

Abstract: Background: Millions of people today use herbs either as food or in the form of medicine along with other medications. Many of the herbs can interact with these medications, causing either potentially dangerous side effects or improved or reduced benefits from the medication.

Objective: The present study was performed to determine the influence of cinnamon, on the pharmacokinetics and pharmacodynamics of pioglitazone.

Method: Studies were conducted in normal and alloxan induced diabetic rats and rabbits with oral administration of selected doses of pioglitazone, cinnamon and their combination. Blood samples were collected at regular intervals of time and were analysed for glucose by GOD/POD method and for pioglitazone by HPLC method respectively. Body weights were also measured every week.

Results: Significant differences were seen in pharmacokinetic parameters of pioglitazone like AUC, t1/2, Ke, Cl/F, Vd/F when given in combination with cinnamon in normal and diabetic rabbits. The combination of pioglitazone and cinnamon was found to reduce the glucose levels and body weights significantly than pioglitazone. The results indicating increased AUC of pioglitazone on pretreatment with cinnamon suggest an interaction indicating decreased metabolism of pioglitazone as a result of CYP 3A4 inhibition and thereby producing a potentiating effect.

Conclusion: Cinnamon enhanced the bioavailability of pioglitazone by inhibiting the CYP3A4 enzyme. Hence, cinnamon might be beneficial when used in combination with pioglitazone in diabetic patients and an adjustment of dose of pioglitazone may be necessary.

Cite this article as:

Mamindla Sandhya, Koganti S.R.G.P. Venkata, Ravouru Nagaraju and Koganti Bharathi*, Effect of Cinnamomum cassia on the Pharmacokinetics and Pharmacodynamics of Pioglitazone, Current Clinical Pharmacology 2017; 12 (1) . https://dx.doi.org/10.2174/1574884712666170207152020

DOI https://dx.doi.org/10.2174/1574884712666170207152020	Print ISSN 1574-8847
Publisher Name Bentham Science Publisher	Online ISSN 2212-3938