Abstract
Background: Skin photodamage exhibits poorly clinical efficacy and so far has rarely satisfactory treatments. Ultraviolet (UV)-induced overproduction of reactive oxygen species (ROS), NF-E2-related factor 2 (Nrf2) inactivation and Nrf2/antioxidant response elements (ARE) signaling pathway blockage play important roles in skin photodamage pathogenesis. Skin-derived precursor cells (SKPs), a population of dermal stem cells, are predominant over wound repair and skin regeneration.
Objective: To hypothesize that SKPs are useful in skin photodamage by Nrf2 activation. Methods: Published papers on skin photodamage and SKPs were collected and reviewed. Besides, the findings from our preliminary experiment were reported in this article. Results: It has been confirmed that stem cells could participate in tissue repair via activating Nrf2 and Nrf2/ARE signal transduction pathway. Furthermore, our previous and current outcomes revealed that SKPs could ameliorate UVB-induced apoptosis or damage and significantly up-regulate Nrf2 expression after UV irradiation. Conclusion: Together the above data, we speculate that SKPs may be good candidates for control of skin photodamage through activating Nrf2 and its signaling pathway. These would provide a new approach for resisting skin photodamage.Keywords: Skin photodamage, skin-derived precursor cells (SKPs), NF-E2-related factor 2 (Nrf2), reactive oxygen species (ROS), ultraviolet (UV), oxidative stress, stem cells.
Graphical Abstract
Current Signal Transduction Therapy
Title:A New Approach for Skin-Derived Precursors to Ameliorate Skin Photodamage Through Activation of Nrf2 Signaling Pathway
Volume: 12 Issue: 1
Author(s): Dehai Xian, Jianqiao Zhong*Xiaoqing Gao
Affiliation:
- Department of Dermatology, Affiliated Hospital of Southwest Medical University, No. 25 Tai Ping Jie, Luzhou, Sichuan 646000,China
Keywords: Skin photodamage, skin-derived precursor cells (SKPs), NF-E2-related factor 2 (Nrf2), reactive oxygen species (ROS), ultraviolet (UV), oxidative stress, stem cells.
Abstract: Background: Skin photodamage exhibits poorly clinical efficacy and so far has rarely satisfactory treatments. Ultraviolet (UV)-induced overproduction of reactive oxygen species (ROS), NF-E2-related factor 2 (Nrf2) inactivation and Nrf2/antioxidant response elements (ARE) signaling pathway blockage play important roles in skin photodamage pathogenesis. Skin-derived precursor cells (SKPs), a population of dermal stem cells, are predominant over wound repair and skin regeneration.
Objective: To hypothesize that SKPs are useful in skin photodamage by Nrf2 activation. Methods: Published papers on skin photodamage and SKPs were collected and reviewed. Besides, the findings from our preliminary experiment were reported in this article. Results: It has been confirmed that stem cells could participate in tissue repair via activating Nrf2 and Nrf2/ARE signal transduction pathway. Furthermore, our previous and current outcomes revealed that SKPs could ameliorate UVB-induced apoptosis or damage and significantly up-regulate Nrf2 expression after UV irradiation. Conclusion: Together the above data, we speculate that SKPs may be good candidates for control of skin photodamage through activating Nrf2 and its signaling pathway. These would provide a new approach for resisting skin photodamage.Export Options
About this article
Cite this article as:
Xian Dehai, Zhong Jianqiao*, Gao Xiaoqing, A New Approach for Skin-Derived Precursors to Ameliorate Skin Photodamage Through Activation of Nrf2 Signaling Pathway, Current Signal Transduction Therapy 2017; 12 (1) . https://dx.doi.org/10.2174/1574362412666170206163620
DOI https://dx.doi.org/10.2174/1574362412666170206163620 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
MMPs in Ovarian Cancer as Therapeutic Targets
Anti-Cancer Agents in Medicinal Chemistry Targeting Hypoxia for Sensitization of Tumors to Radio- and Chemotherapy
Current Cancer Drug Targets Adhesion Mechanisms of the Lyme Disease Spirochete, Borrelia burgdorferi
Current Drug Targets - Infectious Disorders Chemical Modifications of Two Polysaccharides as Drug Carriers
Current Organic Synthesis High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer
Recent Patents on Anti-Cancer Drug Discovery Apoptosis Induction by Erucylphosphohomocholine via the 18 kDa Mitochondrial Translocator Protein: Implications for Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents
Current Cancer Drug Targets Role of the Bone Marrow Microenvironment in Drug Resistance of Hematological Malignances
Current Medicinal Chemistry Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy
Current Medicinal Chemistry Harnessing Phage Display for the Discovery of Peptide-Based Drugs and Monoclonal Antibodies
Current Medicinal Chemistry Chemosensitization and Immunosensitization of Resistant Cancer Cells to Apoptosis and Inhibition of Metastasis by the Specific NF-κB Inhibitor DHMEQ
Current Pharmaceutical Design Differentiation of High-grade Gliomas from Brain Metastases Using Tissue Similarity Maps (TSMs) Based Relative Cerebral Blood Volume Values
Current Medical Imaging Anticancer Drug Combinations, How Far We can Go Through?
Anti-Cancer Agents in Medicinal Chemistry Influence of Aldo-keto Reductase 1C3 in Prostate Cancer - A Mini Review
Current Cancer Drug Targets Potential Benefits of Glitazones for Cancer and Vascular Disease
Current Drug Therapy RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery
Mini-Reviews in Medicinal Chemistry Magnetic Hyperthermia with Magnetic Nanoparticles: A Status Review
Current Topics in Medicinal Chemistry Molecular Mechanisms Regulating Matrix Metalloproteinases
Current Topics in Medicinal Chemistry Drug Repositioning for Treatment of Movement Disorders: From Serendipity to Rational Discovery Strategies
Current Topics in Medicinal Chemistry The Contrasting Roles of NKT Cells in Tumor Immunity
Current Molecular Medicine