摘要
背景:基于视觉的处理速度(VSOP)训练会导致遗忘型轻度认知障碍的老年人广泛认知的改善(aMCI)。然而,尚不清楚的是神经生理学机制如何解释观察到的训练效果。这一领域的许多工作都集中在中枢神经系统上,忽视了外围系统可能导致中枢神经系统改变的事实,反之亦然。 目的:我们研究的潜在关系的自适应副交感神经系统反应的认知刺激和VSOP训练诱发塑性。 方法:二十名aMCI(10 VSOP培训,和11精神的休闲活动(MLA)控制)的患者。我们评估了高频的心率变异性(HF-HRV),在培训期间,和纹状体神经网络与认知相关的基线和岗位培训。 结果:培训期间相比于MLA,VSOP组表现出显著的U型模式的HF-HRV响应,以及双侧纹状体和前额叶区域之间的连接强度降低。这两种效应与训练诱导的训练(注意和加工速度)和转移(工作记忆)认知域的改善有关。 结论:这项工作提供了新的支持中枢和外周神经系统之间的相互作用与认知训练,并推动进一步的研究,以阐明所观察到的环节的因果关系。
关键词: 副交感神经系统,轻度的认知障碍,认知训练、纹状体、加工速度、工作记忆。
Current Alzheimer Research
Title:A Role of the Parasympathetic Nervous System in Cognitive Training
Volume: 14 Issue: 7
关键词: 副交感神经系统,轻度的认知障碍,认知训练、纹状体、加工速度、工作记忆。
摘要: Background: Vision-based speed of processing (VSOP) training can result in broad cognitive improvements in older adults with amnestic mild cognitive impairment (aMCI). What remains unknown, however, is what neurophysiological mechanisms account for the observed training effect. Much of the work in this area has focused on the central nervous system, neglecting the fact that the peripheral system can contributes to changes of the central nervous system and vice versa.
Objective: We examined the prospective relationship between an adaptive parasympathetic nervous system response to cognitive stimuli and VSOP training-induced plasticity. Method: Twenty-one participants with aMCI (10 for VSOP training, and 11 for mental leisure activities (MLA) control) were enrolled. We assessed high-frequency heart rate variability (HF-HRV) during training sessions, and striatum-related neural networks and cognition at baseline and post-training. Results: Compared to MLA, the VSOP group showed a significant U-shaped pattern of HF-HRV response during training, as well as decreases in connectivity strength between bilateral striatal and prefrontal regions. These two effects were associated with training-induced improvements in both the trained (attention and processing speed) and transferred (working memory) cognitive domains. Conclusion: This work provides novel support for interactions between the central and the peripheral nervous systems in relation to cognitive training, and motivates further studies to elucidate the causality of the observed link.Export Options
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Cite this article as:
A Role of the Parasympathetic Nervous System in Cognitive Training, Current Alzheimer Research 2017; 14 (7) . https://dx.doi.org/10.2174/1567205014666170203095128
DOI https://dx.doi.org/10.2174/1567205014666170203095128 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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