TXNIP代谢调节：生理作用和治疗前景

Title:TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

Volume: 18 Issue: 9

关键词: 糖尿病，硫氧还蛋白系统，硫氧还蛋白相互作用蛋白，氧化应激，胰岛素抵抗，胰腺β细胞功能障碍，代谢稳态

摘要: Background & Objective: Thioredoxin-interacting protein (TXNIP) also known as thioredoxin binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates expression and function of Thioredoxin (TXN). Over the last few years, TXNIP has attracted considerable attention due to its wide-ranging functions impacting several aspects of energy metabolism. TXNIP acts as an important regulator of glucose and lipid metabolism through pleiotropic actions including regulation of β-cell function, hepatic glucose production, peripheral glucose uptake, adipogenesis, and substrate utilization. Overexpression of TXNIP in animal models has been shown to induce apoptosis of pancreatic β-cells, reduce insulin sensitivity in peripheral tissues like skeletal muscle and adipose, and decrease energy expenditure. On the contrary, TXNIP deficient animals are protected from diet induced insulin resistance and type 2 diabetes.

Summary: Consequently, targeting TXNIP is thought to offer novel therapeutic opportunity and TXNIP inhibitors have the potential to become a powerful therapeutic tool for the treatment of diabetes mellitus. Here we summarize the current state of our understanding of TXNIP biology, highlight its role in metabolic regulation and raise critical questions that could help future research to exploit TXNIP as a therapeutic target.

Cite this article as:

TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook, Current Drug Targets 2017; 18 (9) . https://dx.doi.org/10.2174/1389450118666170130145514

DOI https://dx.doi.org/10.2174/1389450118666170130145514	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592