Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision

Title:Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision

Volume: 17 Issue: 8

Author(s): Nare Sahakyan, Amir Haddad, Shye Richardson, Valery Forcha-Etieundem, Lee Christopher, Hanan Alharbi and Robert Campbell*

Affiliation:

• Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, 19 Foster St. Worcester, MA 01608,United States

Keywords: Personalized medicine, cancer therapy, drug delivery, nanoparticles, tumor-targeted nanomedicines, nanotechnology.

Abstract: Nanotechnology has brought about the advent of personalized medicine in the era of targeted therapeutic strategies for cancer therapy. The ability to exploit tumor features for therapeutic gain has made it possible to manufacture more effective nanomedicines for cancer treatment. However, known obstacles, including the inability to overcome pathophysiological barriers of tumors, have impeded disease management. In spite of this, recent efforts have been made to develop more functionalized nanosystems that utilize the active-targeting approach. This article reviews the FDA-approved cancer drug delivery systems in the general framework of personalized nanomedicine. We discuss the latest efforts in the development of functionalized nano-systems, and summarize relevant ongoing preclinical and clinical trials.

Cite this article as:

Sahakyan Nare, Haddad Amir, Richardson Shye, Forcha-Etieundem Valery, Christopher Lee, Alharbi Hanan and Campbell Robert*, Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1871520617666170102150730