摘要
背景:植物乳蓟和水飞蓟素传统上被用作治疗各种疾病的天然补救剂已有2000多年的历史,包括神经系统疾病如阿尔茨海默氏症,帕金森病和脑缺血症。 目的:在本文中,我们回顾了水飞蓟素对各种神经功能障碍的神经保护作用。 结果:水飞蓟素赋予的神经保护作用包括调节各种抗氧化机制,以及涉及细胞信号传导途径的几种激酶,抑制神经变性期间产生的炎症反应,神经营养因子,神经递质调节和凋亡抑制。可用性的便利性,比较低的成本和安全性特征为使用该化合物作为具有巨大临床益处的有效药物提供了额外的优点。然而,越来越需要改善水飞蓟素及相关产品的生物利用度,并且需要更一致和可靠的人类试验来准确地验证该天然化合物的神经保护功效。 结论:本综述中提到的研究结果令人期待,提供了对水飞蓟素在神经变性和神经退行性疾病与疾病进展病理学相关的各种神经变性疾病中的临床相关性的深入了解。
关键词: 阿尔茨海默病,神经退行性疾病,帕金森病,水飞蓟素,神经保护作用,氧化应激。
图形摘要
Current Drug Targets
Title:A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin
Volume: 18 Issue: 13
关键词: 阿尔茨海默病,神经退行性疾病,帕金森病,水飞蓟素,神经保护作用,氧化应激。
摘要: Background: The plant milk thistle and silymarin has been traditionally used as a natural remedy for the treatment of various ailments including neurological disorders such as Alzheimer’s and Parkinson's disease and cerebral ischemia for over 2000 years.
Objective: In this article we review the neuroprotective effects of silymarin against various neurological dysfunctions. Results: The neuroprotective effects conferred by silymarin include modulation of various antioxidant mechanisms, and several kinases involved in cell signaling pathways, inhibition of the inflammatory response generated during neurodegeneration, neurotropic effects, regulation of neurotransmitters and inhibition of apoptosis. The ease of availability, comparative low cost and safety profile provide additional advantages for the use of this compound as a potent drug with immense clinical benefit. However, there is a growing need for improvements in the bioavailability of silymarin and related products, and more consistent and reliable human trials are required to accurately validate the neuroprotective efficacy of this natural compound. Conclusion: The promising outcomes of the studies mentioned in this review provide renewed insight into the clinical relevance of silymarin in a variety of neurodegenerative disorders where neuroinflammation and oxidative stress are pathologically relevant to disease progression.Export Options
About this article
Cite this article as:
A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161227125121
DOI https://dx.doi.org/10.2174/1389450117666161227125121 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Toll-Like Receptors in Alzheimer's Disease: A Therapeutic Perspective
CNS & Neurological Disorders - Drug Targets Epigenetic Modulation: A Promising Avenue to Advance Hematopoietic Stem Cell-Based Therapy for Severe Autoimmune Disorders
Epigenetic Diagnosis & Therapy (Discontinued) Peptides in Oral Diseases
Current Pharmaceutical Design Differences in Relative Levels of 88 microRNAs in Various Regions of the Normal Adult Human Brain
MicroRNA Chemokines and Brain Functions
Current Drug Targets - Inflammation & Allergy Systemic Sclerosis at the Cellular Level: Molecular Pathways of Pathogenesis and its Implication on Future Drug Design
Current Medicinal Chemistry Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors
Current Neurovascular Research Allergic Contact Dermatitis: Novel Mechanisms and Therapeutic Perspectives
Current Drug Metabolism The Tumor Suppressor Gene ARF as a Sensor of Oxidative Stress
Current Molecular Medicine Phenylbutyric Acid Protects Against Spatial Memory Deficits in a Model of Repeated Electroconvulsive Therapy
Current Neurovascular Research Discordant Tissue-Specific Expression of SAPK/MAPKJNK-Related Cofactors in Hypoxia and Hypoxia/Reoxygenation in a Model of Anoxia-Tolerance
Protein & Peptide Letters Neurokinin-1 Receptor (NK-1R) Antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme
Current Medicinal Chemistry Neurosteroids and Sporadic Alzheimers Disease
Current Alzheimer Research ABC Transporters in Extrahepatic Tissues: Pharmacological Regulation in Heart and Intestine
Current Medicinal Chemistry Soluble Forms of RAGE in Human Diseases: Clinical and Therapeutical Implications
Current Medicinal Chemistry Cerebrovascular Complications of Diabetes: SGLT-2 Inhibitors as a Promising Future Therapeutics
Current Drug Targets New Therapeutic Strategies in Perinatal Stroke
Current Drug Targets - CNS & Neurological Disorders Understanding the Multifaceted Role of Inflammatory Mediators in Ischemic Stroke
Current Medicinal Chemistry Inducible Nitric Oxide Synthase as a Possible Target in Hypertension
Current Drug Targets microRNA as Biomarkers and Regulator of Cardiovascular Development and Disease
Current Pharmaceutical Design