摘要
α晶状体球蛋白,最初被鉴定为眼透镜的结构蛋白,属于小热休克蛋白家族。他们在维持晶状体透明度和防止蛋白质聚集方面发挥重要作用。α晶状体球蛋白有两种同工型:αA和αB,他们在组织中分布有显著差异。他们的突变涉及几种人类疾病包括心脏病、神经变性疾病、白内障和各种类型的癌症。在视网膜母细胞瘤、乳腺癌、胶质母细胞瘤、前列腺和肾细胞癌中检测到增加的αB表达,表明其在促进肿瘤生长中的作用。复合图像出现为αA,虽然早期的研究表明αA可能促进癌症的发展,我们实验室最近的研究表明αA能够作为肿瘤抑制剂抑制细胞转化和通过调节MAP激酶活性组织细胞迁移。本文我们对近期癌症发展中αA和αB功能的进展进行了综述。
关键词: αA,αB,肿瘤,晶状体球蛋白
Current Molecular Medicine
Title:Contrast Functions of αA- and αB-Crystallins in Cancer Development
Volume: 16 Issue: 10
关键词: αA,αB,肿瘤,晶状体球蛋白
摘要: α-Crystallins, initially identified as the structural proteins of the ocular lens, belong to the small heat shock protein family. They play significant roles in maintaining the lens transparency and preventing protein aggregation. α-Crystallins exist in two isoforms: αA and αB, and they display differential tissue distribution. Their mutations are implicated in several human diseases including cardiac myopathies, neurodegenerative diseases, cataracts and various types of cancers. Increased αB expression was detected in retinoblastoma, breast cancer, glioblastoma, prostate and renal cell carcinomas, indicating its role in promoting tumor growth. A complex picture emerges for αA. Although earlier studies suggest that αA may promote cancer development, recent studies from our laboratory demonstrate that αA can act as a tumor suppressor inhibiting cell transformation and retarding cell migration through modulating MAP kinase activity. In this review, we summarize the recent progress about the functions of αA and αB in cancer development.
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Cite this article as:
Contrast Functions of αA- and αB-Crystallins in Cancer Development, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223110508
DOI https://dx.doi.org/10.2174/1566524016666161223110508 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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