摘要
心脏是一个非常重要的器官,并且心血管紊乱在生活中是威胁生命的主要疾病。心血管蛋白中异常的蛋白质翻译后修饰(PTMs)与心脏病理性异常非常相关。SUMO化修饰作为最受欢迎的PTMs之一,细胞中有着成千上万的基板,也在心脏研究中表现出能够精准的控制细胞的存活和繁殖,能够针对性地控制线粒体和肌浆网生理心脏功能的作用。万幸的是病理心脏SUMO修饰化被视为心血管疾病的干预和治疗目标。因此,本文对近年来心脏方面SUMO化修饰通路的功能进行了综述。尤其讨论了心血管发育和包括心肌线粒体功能、心肌收缩力、稳态应力适应和蛋白质的心血管健康SUMO化修饰或解离的生物学意义。我们还讨论了SUMO化修饰等翻译后修饰的的乙酰化和泛素化之间的关系。这些关系不仅为我们对心血管紊乱调整机制的知识增进了理解,也对未来治疗作出了贡献。
关键词: SUMO化修饰,线粒体,肌内质网Ca2+-atp酶,组蛋白去乙酰化酶,心衰
Current Molecular Medicine
Title:Roles of SUMOylation in Heart Development and Cardiovascular Diseases
Volume: 16 Issue: 10
关键词: SUMO化修饰,线粒体,肌内质网Ca2+-atp酶,组蛋白去乙酰化酶,心衰
摘要: Heart is an extremely important organ, and cardiovascular disorders emerge as primary life-threatening disease in human life. Aberrant post-translational modifications (PTMs) on cardiac proteins are closely correlated with pathological abnormalities in heart. SUMOylation, one of the most prevalent PTMs with thousands of substrates throughout the cell including critical subcellular organelles, has been shown to precisely finetune the cell survival and proliferation during heart development, and delicately control the function of mitochondrion and sarcoplasmic reticulum in physiological heart functioning. The silver lining is pathologically cardiacspecific SUMOylation being considered as target for cardiovascular disease intervention and treatment. Here, we summarize the recent progress in heart-specific functions of the SUMOylation pathway. In particular, we discuss the biological significance of SUMO conjugation/deconjugation during heart development, and in physiological cardiovascular health involving cardiac mitochondrial function, cardiac contractility, stress adaption and protein homeostasis. We also discuss the crosstalks between sumoylation and other post-translational modifications such as acetylation and ubiquitination. These crosstalks not only shed light to our understanding of the regulatory mechanisms on cardiovascular disorders but also contributes to their future therapy.
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Cite this article as:
Roles of SUMOylation in Heart Development and Cardiovascular Diseases, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223110407
DOI https://dx.doi.org/10.2174/1566524016666161223110407 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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