摘要
后翻译修饰(PTMs)如磷酸化、酯化、甲基化、泛素化、SUMO化都是在调节不同蛋白很重要的机制。在各种PTMs中,磷酸化发现于60年前,可能是最常见的修饰。相反,发现于20年前的SUMO化正在作为一种关键的调节机制介导蛋白功能。虽然蛋白磷酸化和SUMO化已经被广泛的研究,但很少有人关注其对同一个蛋白靶点的关联和共调。在此我们对蛋白磷酸化和SUMO化之间的关联的例子进行了总结,并讨论了他们在调节正常通路和病理通路的功能
关键词: PTM,磷酸化,SUMO化,蛋白功能
Current Molecular Medicine
Title:Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases
Volume: 16 Issue: 10
关键词: PTM,磷酸化,SUMO化,蛋白功能
摘要: Post-translational modifications (PTMs) such as phosphorylation, acetylation, methylation, ubiquitylation, sumoylation are important mechanisms to regulate functions of different proteins. Among various PTMs, phosphorylation, discovered about 60 years ago, is probably the most common modification. In contrast, sumoylation, identified about two decades ago is emerging as a key regulatory mechanism modulating protein functions. Although studies on protein phosphorylation and sumoylation have been extensively reviewed, much less attention has been paid to their cross-talk and their co-regulation of the same protein target. Here we summarize various examples of the cross-talks between protein phosphorylation and sumoylation, and discuss their functions in regulating normal physiology and pathogenesis.
Export Options
About this article
Cite this article as:
Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223105555
DOI https://dx.doi.org/10.2174/1566524016666161223105555 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
In Vivo Tumor Secretion Probing Via Ultrafiltration and Tissue Chamber:Implication for Anti-Cancer Drugs Targeting Secretome
Recent Patents on Anti-Cancer Drug Discovery Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance
Current Medicinal Chemistry Recent Patents Review on Intranasal Administration for CNS Drug Delivery
Recent Patents on Drug Delivery & Formulation Statins and Type 2 Diabetes Mellitus: An Update After 1 Year
Current Pharmaceutical Design PET Radiopharmaceuticals for Personalized Medicine
Current Drug Targets Electric cable: cytoskeleton as an electric transmitter for cancer therapy
Current Signal Transduction Therapy Tumor Suppression by DNA Base Excision Repair
Mini-Reviews in Medicinal Chemistry Application of Chitosan and Propolis in Endodontic Treatment: A Review
Mini-Reviews in Medicinal Chemistry Nano-Enabled Drug Delivery in Cancer Therapy: Literature Analysis Using the MeSH System
Pharmaceutical Nanotechnology Cancer Immunotherapy: Battling Tumors with Gene Vaccines
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Onconeural Versus Paraneoplastic Antigens?
Current Medicinal Chemistry Natural Polymeric Nanoparticles for Brain-Targeting: Implications on Drug and Gene Delivery
Current Pharmaceutical Design Combined Treatment with Laser Ablation and Tyrosine-Kinase Inhibitor as A Novel Multimodality Approach to Locally Advanced Thyroid Cancer: A Case Report
Endocrine, Metabolic & Immune Disorders - Drug Targets Biomedical Applications of Accelerator Mass Spectrometry
Current Analytical Chemistry Evaluation of Vitamin C as a Personalized Adjuvant Medicine: Pharmacogenomic Studies
Current Pharmacogenomics and Personalized Medicine MRI Evaluation Using DWI and T2WI of Residual Lymph Nodes in patients Affected by Head and Neck Squamous Cell Carcinoma Treated with Chemo-Radiotherapy
Current Medical Imaging High Order Texture-Based Analysis in Biomedical Images
Current Medical Imaging Bone Target Radiotracers for Palliative Therapy of Bone Metastases
Current Medicinal Chemistry Application of Diet-derived Taste Active Components for Clinical Nutrition: Perspectives from Ancient AyurvedicMedical Science, Space Medicine, and Modern Clinical Nutrition
Current Pharmaceutical Design