摘要
后翻译修饰(PTMs)如磷酸化、酯化、甲基化、泛素化、SUMO化都是在调节不同蛋白很重要的机制。在各种PTMs中,磷酸化发现于60年前,可能是最常见的修饰。相反,发现于20年前的SUMO化正在作为一种关键的调节机制介导蛋白功能。虽然蛋白磷酸化和SUMO化已经被广泛的研究,但很少有人关注其对同一个蛋白靶点的关联和共调。在此我们对蛋白磷酸化和SUMO化之间的关联的例子进行了总结,并讨论了他们在调节正常通路和病理通路的功能
关键词: PTM,磷酸化,SUMO化,蛋白功能
Current Molecular Medicine
Title:Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases
Volume: 16 Issue: 10
关键词: PTM,磷酸化,SUMO化,蛋白功能
摘要: Post-translational modifications (PTMs) such as phosphorylation, acetylation, methylation, ubiquitylation, sumoylation are important mechanisms to regulate functions of different proteins. Among various PTMs, phosphorylation, discovered about 60 years ago, is probably the most common modification. In contrast, sumoylation, identified about two decades ago is emerging as a key regulatory mechanism modulating protein functions. Although studies on protein phosphorylation and sumoylation have been extensively reviewed, much less attention has been paid to their cross-talk and their co-regulation of the same protein target. Here we summarize various examples of the cross-talks between protein phosphorylation and sumoylation, and discuss their functions in regulating normal physiology and pathogenesis.
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Cite this article as:
Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223105555
DOI https://dx.doi.org/10.2174/1566524016666161223105555 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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