摘要
背景技术:选择性剪接是后转录修饰之一,其中多个mRNA同种型从任何基因(也称为剪接变体)产生。这些在组织和发育阶段的具体方式表达,在发展过程中是重要的。大多数人类基因经历可变剪接,从而有助于蛋白质的多样性。然而,许多异常剪接过程可能导致人类疾病。非甾体抗炎药(NSAIDs)是通过影响Cox基因及其产物作为止痛剂,抗热解剂和抗炎药物。通常,NSAIDs会引起胃肠毒素,但同功酶特异性NSAIDs具有相对降低的胃毒性作用。 NSAIDs具有更广泛的应用范围,特别是作为化学预防药物。众所周知,酶的活性位点的变化可能会使不同程度的反应产生违法。这种变化可能解释了为什么患者似乎对不同NSAID有不同反应的根本原因。 方法:使用Pubmed和科学数据库网络进行广泛的文献检索,考虑了近10年来的论文,主要涉及可变剪接和NSAID。 结论:我们详细审查了针对不同基因的特异性亚型的NSAIDs的作用。未来,对NSAIDs相关基因及其表达研究的全面了解可能有助于产生具有更高特异性的药物。
关键词: 选择性剪接,NSAIDs,癌症,COX,Rac-1b,KLF-4,PPARγ,PKCβ1。
图形摘要
Current Cancer Drug Targets
Title:NSAIDs Induced Regulation of Alternatively Spliced Transcript Isoforms: Possible Role in Cancer and Alzheimer Disease
Volume: 17 Issue: 5
关键词: 选择性剪接,NSAIDs,癌症,COX,Rac-1b,KLF-4,PPARγ,PKCβ1。
摘要: Background: Alternative splicing is one of the post transcriptional modifications through which multiple mRNA isoforms are produced from any gene, also known as splice variants. These are expressed in tissue and developmental stage specific manner that are important during the development. Most human genes undergo alternative splicing, thus contributing to the diversity of proteins. However, many abnormal splicing processes may result in human diseases. Non-steroidal antiinflammatory drugs (NSAIDs) are medications that act as analgesics, anti-pyretics and antiinflammatory by affecting Cox genes and their products. Usually NSAIDs cause gastrotoxicity however, isozyme-specific NSAIDs exhibit a comparatively reduced gastrotoxic effect. Such NSAIDs have a broader range of application particularly as chemo-preventive drugs. It is known that changes at the active site of an enzyme may illicit a diverse range of responses. Such changes might explain the underlying reason as to why patients appear to respond differently to different NSAIDs.
Methods: An extensive literature search has been carried out using Pubmed and web of science databases considering the papers in last 10 years mainly on alternative splicing and NSAIDs. Conclusion: We have reviewed in detail the insight into the action of NSAIDs targeting specific isoforms of different genes. In future, the complete understanding of NSAIDs associated genes and their expression studies may be helpful in generating drugs with increased specificity.Export Options
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Cite this article as:
NSAIDs Induced Regulation of Alternatively Spliced Transcript Isoforms: Possible Role in Cancer and Alzheimer Disease, Current Cancer Drug Targets 2017; 17 (5) . https://dx.doi.org/10.2174/1568009616666161216093403
DOI https://dx.doi.org/10.2174/1568009616666161216093403 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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