进一步目标：胶质瘤干细胞在成胶质细胞瘤治疗中新的方法

Title:Hitting a Moving Target: Glioma Stem Cells Demand New Approaches in Glioblastoma Therapy

Volume: 17 Issue: 3

关键词: 化疗，药物靶向，多形性成胶质细胞瘤，胶质瘤干细胞，生态位，阻力，重现

摘要: Background: Glioblastoma multiforme (GBM) continues to devastate patients and outfox investigators and clinicians despite the preponderance of research directed at its biology, pathogenesis and therapeutic advances. GBM routinely outlasts multidisciplinary treatment protocols, almost inevitably recurring in a yet more aggressive and resistant form with distinct genetic differences from the original tumor. Attempts to glean further insight into GBM point increasingly toward a subpopulation of cells with a stem-like phenotype. These cancer stem cells, similar to those now described in a variety of malignancies, are capable of tumorigenesis from a population of susceptible cells.

Cite this article as:

Hitting a Moving Target: Glioma Stem Cells Demand New Approaches in Glioblastoma Therapy, Current Cancer Drug Targets 2017; 17 (3) . https://dx.doi.org/10.2174/1568009616666161215161924