摘要
背景:在阿尔兹海默病(AD)中是否运动能够延迟意识功能衰退和结构性改变还没有完全被弄清。 方法:6个月的雄性APP/PS1双转基因小鼠跑四个月,然后研究运动对AD小鼠意识功能和白质的影响。 结果:当与不动组相比较,运动组的逃避潜伏期显著减少。当与不动组比较,运动组的目标象限次数百分比和目标区域频率都显著增加。当与不动组比较,运动组的白质体积、有髓纤维体积和在白质中的轴突体积显著增加。 结论:在AD患者中,运动能增加意识功能,在AD患者的白质中运动的影响可能是运动保护AD患者的意识功能的其中一个结构基础。运动保护AD患者的白质可能由于运动防止AD患者的白质有髓纤维脱髓鞘。
关键词: 阿尔兹海默病,转基因小鼠,运动,有髓纤维,白质,体视学。
Current Alzheimer Research
Title:Exercise Prevents Cognitive Function Decline and Demyelination in the White Matter of APP/PS1 Transgenic AD Mice
Volume: 14 Issue: 6
关键词: 阿尔兹海默病,转基因小鼠,运动,有髓纤维,白质,体视学。
摘要: Background: Whether exercise could delay the cognitive function decline and structural changes in Alzheimer’s disease (AD) are not fully understood.
Methods: 6-month-old male APP/PS1 double transgenic mice ran four months and then the effects of exercise on the cognitive function and the white matter of AD were investigated. Results: The mean escape latency of the excercised group was significantly shortened when compared to that of the sedentary group. The percentage of time in target quadrant and the target zone frequency of the exercised group were significantly increased when compared to the sedentary group. The white matter volume, the myelinated fiber volume and axon volume in the white matter of the exercised group were significantly increased when compared to the sedentary group. Conclusion: Exercise could improve the cognitive function in AD, and the effects of exercise on the white matter of AD might be one of the structural bases for the protective effect of exercise on the cognitive function of AD. The exercise-induced protection of the white matter in AD might be due to the fact that the exercise prevented the demyelination of the myelinated fibers in the white matter of AD.Export Options
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Cite this article as:
Exercise Prevents Cognitive Function Decline and Demyelination in the White Matter of APP/PS1 Transgenic AD Mice, Current Alzheimer Research 2017; 14 (6) . https://dx.doi.org/10.2174/1567205014666161213121353
DOI https://dx.doi.org/10.2174/1567205014666161213121353 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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