人类宿主防御肽—在维持人类稳态和病理过程的作用

Title:Human Host Defense Peptides - Role in Maintaining Human Homeostasis and Pathological Processes

Volume: 24 Issue: 7

关键词: 抗微生物肽、导管素、防御素、牛皮藓、特应性皮炎、囊性纤维化、慢性阻塞性肺疾病、牙周炎、关节炎、动脉粥样硬化。

摘要: The human body expresses over 100 host defense peptides and proteins (antimicrobial peptides, AMPs). The compounds are produced by tissues and mucosal surfaces, e.g. skin, the digestive and urinary tract, the ocular surface and neutrophils, and are believed to play a crucial role in defense from microbial infection. They are considered to protect the human body against microbial infections due to their antimicrobial and immunomodulatory activities. As well as having strong antimicrobial activity towards a broad spectrum of microorganisms, AMPs have been found to interact with neutrophils, monocytes and T-cells and promote the production of cytokines. They also neutralize the action of lipopolysaccharide (LPS) and play a crucial role in wound healing processes.

Cite this article as:

Human Host Defense Peptides - Role in Maintaining Human Homeostasis and Pathological Processes, Current Medicinal Chemistry 2017; 24 (7) . https://dx.doi.org/10.2174/0929867323666161213100443